Programa de Pós-graduação em Ciências (Fisiologia Humana), Instituto de Ciências Biológicas, Universidade de São Paulo, Sao Paulo/SP 05508900, Brazil.
Escola de Educação Física, Universidade de Pernambuco, Recife/PE 50740-465, Brazil.
Mar Drugs. 2020 Jan 29;18(2):89. doi: 10.3390/md18020089.
The blue alga has presented several pharmacological activities, highlighting its actions as an anti-inflammatory and antioxidant. In addition, there are few studies with the influence of strength training on physiological parameters, as intestinal contractility and oxidative cell damage. We evaluated the influence of supplementation, strength training, and its association on contractile reactivity of rat ileum, as well as the balance of oxidative stress/antioxidant defenses. Methods: Male Wistar rats were divided into; sedentary (S); S + supplemented with algae at 50 (S50), 150 (S150), and 500 mg/kg (S500); trained (T); and T + supplemented (T50, T150, and T500). Contractile reactivity was analyzed by kymographs; oxidative stress on ileum by the malondialdehyde (MDA) formation; and the antioxidant capacity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. supplementation reduced the reactivity of rat ileum to carbachol (CCh) and KCl, while training reduced only the CCh efficacy. In addition, association potentiated the reduction on contractile reactivity. Supplementation reduced the oxidative stress and increased oxidation inhibition; training alone did not alter this parameter, however association potentiated this beneficial effect. Therefore, this study demonstrated that both supplementation and its association with strength training promote beneficial effects regarding intestinal contractile reactivity and oxidative stress, providing new insights for intestinal disorders management.
蓝藻具有多种药理活性，其抗炎和抗氧化作用尤为突出。此外，关于力量训练对肠道收缩性和氧化细胞损伤等生理参数的影响的研究较少。我们评估了补充、力量训练及其联合对大鼠回肠收缩反应性的影响，以及氧化应激/抗氧化防御的平衡。方法：雄性 Wistar 大鼠分为：久坐（S）；S+补充 50（S50）、150（S150）和 500mg/kg（S500）的藻类；训练（T）；以及 T+补充（T50、T150 和 T500）。通过动图分析收缩反应性；通过丙二醛（MDA）形成分析回肠的氧化应激；通过 2,2-二苯基-1-苦基肼（DPPH）法分析抗氧化能力。补充降低了大鼠回肠对卡巴胆碱（CCh）和氯化钾（KCl）的反应性，而训练仅降低了 CCh 的功效。此外，联合作用增强了收缩反应性的降低。补充降低了氧化应激并增加了氧化抑制；单独训练没有改变这一参数，但联合作用增强了这种有益作用。因此，本研究表明，补充剂及其与力量训练的联合使用对肠道收缩反应性和氧化应激都有有益的影响，为肠道紊乱的管理提供了新的思路。
