对 HBS Ag(+)、HBV DNA PCR(+) 和 HBV DNA PCR(-) 受试者唾液β-2微球蛋白作为乙肝病毒增殖标志物的评估。
Evaluation of salivary beta-2 microglobulin as HBV proliferation marker in HBS Ag(+), HBV DNA PCR(+) and HBV DNA PCR(-) subjects.
作者信息
Abdolsamadi Hamidreza, Eini Peiman, Ronasi Negin, Kaboli Seyed Alireza, Hajilooei Mehrdad, MoghimBeigi Abbas, Davoudi Poorandokht, AhmadiMotemayel Fatemeh, Shalmani Hamid Mohaghegh
机构信息
Department of Oral Medicine, School of Dentistry, Dentistry Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Infectious Diseases, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Gastroenterol Hepatol Bed Bench. 2013;6(Suppl 1):S105-11.
AIM
The aim of this study was to determine the concentration of salivary B2M as a marker of viral proliferation in HBS Ag(+), HBV DNA PCR(+) and Hbs Ag(+) and HBV DNA PCR(-) subjects.
BACKGROUND
Beta-2 microglobulin (B2M) is responsible for transmission of viral antigens such as Hepatitis B (HBV) on the surface of liver cells as part of an HLA complex.
PATIENTS AND METHODS
In this case control study, 25 PCR(+) and 2 PCR(-) patients were included. 5 mL of the saliva sample was obtained from all patients and salivary B2M level was measured using nephelometer. The data was evaluated by the descriptive, chi square and t tests.
RESULTS
72% of the PCR(+) patients received medications and in contrast, 85.7% of the patients with PCR(-) did not take any medication (P < 0.001). The average salivary concentration ofBeta-2 microglobulin in the PCR(+) group (5.28 ± 5.45 mg/deciliter) was more than PCR(-) group (1.51±0.77) and this difference was statistically significant (P = 0.003).
CONCLUSION
The salivary B2Mlevel can be used as a marker of viral proliferation in patients with hepatitis B.
目的
本研究旨在测定唾液中β2微球蛋白（B2M）的浓度，作为乙肝表面抗原（HBS Ag）阳性、乙肝病毒DNA聚合酶链反应（HBV DNA PCR）阳性以及乙肝表面抗原阳性且乙肝病毒DNA聚合酶链反应阴性患者病毒增殖的标志物。
背景
β2微球蛋白（B2M）作为人类白细胞抗原（HLA）复合体的一部分，负责在肝细胞表面传递诸如乙肝病毒（HBV）等病毒抗原。
患者与方法
在这项病例对照研究中，纳入了25例PCR阳性和2例PCR阴性患者。从所有患者处采集5毫升唾液样本，使用散射比浊法测定唾液中B2M水平。通过描述性统计、卡方检验和t检验对数据进行评估。
结果
72%的PCR阳性患者接受了药物治疗，相比之下，85.7%的PCR阴性患者未服用任何药物（P < 0.001）。PCR阳性组中β2微球蛋白的平均唾液浓度（5.28±5.45毫克/分升）高于PCR阴性组（1.51±0.77），且这种差异具有统计学意义（P = 0.003）。
结论
唾液中B2M水平可作为乙肝患者病毒增殖的标志物。
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