Department of Surgery D, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Anaesthesia. 2014 Oct;69(10):1163-71. doi: 10.1111/anae.12717. Epub 2014 May 19.
We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I(2) 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.
我们系统地回顾了围手术期褪黑素的随机对照试验。我们纳入了 24 项研究，共纳入了 1794 名参与者，报告了 8 项围手术期结局：焦虑；镇痛；睡眠质量；氧化应激；苏醒行为；麻醉需求；盗血诱导；安全性。与安慰剂相比，褪黑素降低了术前焦虑评分的标准化均数差（95%置信区间）0.88（0.44-1.33）和术后疼痛评分 1.06（0.23-1.88）。由于存在很大的统计学异质性，效应幅度不可靠，分别为 I(2)87%和 94%。定性综述表明褪黑素可以改善睡眠质量和苏醒行为，并且可能能够减轻氧化应激和麻醉需求。
