Bulpitt C J, Fletcher A E
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
J Cardiovasc Pharmacol. 1989;14 Suppl 10:S21-6; discussion S59-62.
In this article, the issues involved in the measurement of quality of life (QL) in clinical trials of anti-hypertensive drugs in the elderly are discussed. The specific choice of areas of QL to measure will be influenced by such factors as the length of the trial and the expected adverse effects or benefits of treatment. In measuring QL one should use methods that are valid, repeatable, and sensitive to change. With the elderly, interviewer-administered methods are preferable to self-administered ones, as subjects in poor health or with reading problems should be included. Interpretation of the results from the pilot trial of the Systolic Hypertension in the Elderly Program (SHEP) are discussed.
本文讨论了老年高血压药物临床试验中生活质量（QL）测量所涉及的问题。测量QL的具体领域选择将受到试验时长以及治疗预期不良反应或益处等因素的影响。在测量QL时，应使用有效、可重复且对变化敏感的方法。对于老年人，采用访谈者实施的方法优于自我实施的方法，因为应纳入健康状况不佳或有阅读困难的受试者。文中还讨论了老年收缩期高血压计划（SHEP）试点试验结果的解读。
