State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China; Military Veterinary Institute, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China.
Military Veterinary Institute, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China.
Lancet Infect Dis. 2014 Aug;14(8):763-772. doi: 10.1016/S1473-3099(14)70718-2. Epub 2014 May 15.
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging haemorrhagic fever that was first described in rural areas of China. The causative agent, SFTS virus (SFTSV), is a novel phlebovirus in the Bunyaviridae family. Since the first report in 2010, SFTS has been found in 11 provinces of China, with about 2500 reported cases, and an average case-fatality rate of 7·3%. The disease was also reported in Japan and Korea in 2012; Heartland virus, another phlebovirus genetically closely related to SFTSV, was isolated from two patients in the USA. The disease has become a substantial risk to public health, not only in China, but also in other parts of the world. The virus could undergo rapid evolution by gene mutation, reassortment, and homologous recombination in tick vectors and vertebrate reservoir hosts. No specific treatment of SFTS is available, and avoiding tick bites is an important measure to prevent the infection and transmission of SFTSV. This Review provides information on the molecular characteristics and ecology of this emerging tick-borne virus and describes the epidemiology, clinical signs, pathogenesis, diagnosis, treatment, and prevention of human infection with SFTSV.
严重发热伴血小板减少综合征（SFTS）是一种新发的出血热，最初在中国农村地区被发现。病原体为 SFTS 病毒（SFTSV），是布尼亚病毒科的一种新型沙粒病毒。自 2010 年首次报告以来，SFTS 已在中国 11 个省发现，报告病例约 2500 例，平均病死率为 7.3%。2012 年，日本和韩国也报告了该病；在美国的两名患者中分离到另一种与 SFTSV 基因密切相关的沙粒病毒，称为 Heartland 病毒。该病已成为中国乃至世界公共卫生的重大威胁。病毒在蜱媒介和脊椎动物储存宿主中可通过基因突变、重配和同源重组快速进化。目前尚无 SFTS 的特效治疗方法，避免蜱叮咬是预防 SFTSV 感染和传播的重要措施。本综述提供了有关这种新发蜱传病毒的分子特征和生态学信息，并描述了 SFTSV 所致人类感染的流行病学、临床特征、发病机制、诊断、治疗和预防。
