Sunami K, Nakamura T, Kubota M, Ozawa Y, Namba H, Yamaura A, Makino H
Neurol Med Chir (Tokyo). 1989 Nov;29(11):975-80. doi: 10.2176/nmc.29.975.
The direct current (DC) potential and electroencephalographic (EEG) changes were continuously monitored following fluid percussion head injury (brain contusion) in 10 conscious rats. Local cerebral glucose utilization (LCGU) was measured by the autoradiographic [14C]deoxyglucose method. Measurement of LCGU was started at the lowest point of the first or second DC potential negative shift when it occurred, and 2 hours after contusion if no DC potential changes were observed. The DC potential did not change in four rats (Group A), whereas DC potential negative shifts together with marked suppression of EEG activity occurred at 54 +/- 6.9 minutes after injury in six rats (Group B). In Group A, LCGU was decreased nonsignificantly in both the right and left cortices. In Group B, however, LCGU in the lesioned cortex rose to 160-190% of the level observed in the contralateral cortex (p less than 0.05). The autoradiographic pattern in Group B was identical to that seen in spreading depression. These findings can contribute to the effort to better understand the pathophysiology of head injury.
对10只清醒大鼠进行液体冲击性头部损伤（脑挫伤）后，持续监测其直流（DC）电位和脑电图（EEG）变化。采用放射自显影[14C]脱氧葡萄糖法测量局部脑葡萄糖利用（LCGU）。当首次或第二次DC电位负向偏移处于最低点时开始测量LCGU，若未观察到DC电位变化，则在挫伤后2小时开始测量。4只大鼠（A组）的DC电位未发生变化，而6只大鼠（B组）在损伤后54±6.9分钟出现DC电位负向偏移并伴有EEG活动明显抑制。在A组中，左右皮质的LCGU均无明显下降。然而，在B组中，损伤皮质的LCGU升至对侧皮质观察水平的160 - 190%（p < 0.05）。B组的放射自显影模式与扩散性抑制所见相同。这些发现有助于更好地理解头部损伤的病理生理学。
