Inflammation Program, University of Iowa, Iowa City, Iowa; Department of Internal Medicine, University of Iowa, Iowa City, Iowa; Veterans Affairs Medical Center, Iowa City, Iowa.
Ann N Y Acad Sci. 2014 Jun;1319(1):82-95. doi: 10.1111/nyas.12458. Epub 2014 May 19.
Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen- and damage-associated molecular patterns into a proinflammatory response. This potent caspase-1-dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of programmed cell death), and shaping adaptive immunity. The NLRP3 inflammasome is the most thoroughly studied of the inflammasome complexes that have been described thus far, perhaps owing to its disparate assortment of agonists. This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome.
由于其将病原体和损伤相关分子模式的各种信号整合到促炎反应中的独特能力，炎性小体继续引起越来越多的学科的兴趣。这种有效的半胱天冬酶-1依赖性过程能够激活先天免疫系统，引发细胞焦亡（一种炎症形式的程序性细胞死亡），并塑造适应性免疫。NLRP3 炎性小体是迄今为止描述的炎性小体复合物中研究最透彻的一种，这也许归因于其不同的激动剂。本综述强调了我们目前对 NLRP3 炎性小体的启动和激活机制的理解。
