Saloniemi H, Kalima T V, Rahko T
Acta Vet Scand. 1989;30(4):367-70. doi: 10.1186/BF03548011.
The effect of pancreatic enzyme preparation (Combizyme Forte granulate) on the growth rate of normal, sham-operated and pancreatic duct ligated growing pigs was studied in 2 trials. In the first trial 6 normal Yorkshire pigs were fed a pancreatic enzyme supplement and 6 other pigs from the same litter were fed without supplementation. The growth rate over a period of 4 weeks was not significantly greater in the supplemented group. In a second trial exocrine pancreatic insufficiency, without diabetic symptoms, was produced in 12 pigs (aged 1.5 months and weighing 14 kgs) by ligation of the main pancreatic duct. The growth rates over a period of 20 days after surgery were 240 g, 454 g and 483 g/day in ligated pigs, in ligated pigs supplemented with pancreatic enzyme and in sham-operated control pigs, respectively. The difference between the ligated groups was significant (p less than 0.01) indicating the efficiency of the pancreatic enzyme therapy.
在两项试验中研究了胰酶制剂（Combizyme Forte颗粒剂）对正常、假手术和胰管结扎的生长猪生长速率的影响。在第一项试验中，给6只正常的约克夏猪喂食胰酶补充剂，同一窝的另外6只猪不喂食补充剂。补充组在4周内的生长速率没有显著提高。在第二项试验中，通过结扎主胰管，在12头猪（1.5月龄，体重14千克）中造成了无糖尿病症状的外分泌性胰腺功能不全。术后20天内，结扎猪、补充胰酶的结扎猪和假手术对照猪的生长速率分别为每天240克、454克和483克。结扎组之间的差异显著（p小于0.01），表明胰酶疗法有效。
