Rahko T, Kalima T V, Saloniemi H
Acta Vet Scand. 1987;28(3-4):285-9. doi: 10.1186/BF03548595.
Morphological changes of pancreatic tissue in young pigs caused by surgical ligation of the main pancreatic duct are described. Nineteen animals from 6 to 7 weeks in age were operated on and necropsied 3 or 6 to 8 weeks later. Twelve pigs developed a pronounced chronic pancreatitis with complete exocrine insufficiency. Of the 7 animals failing to develop ectasia of pancreatic ducts, 2 died due to surgical complications. In addition, 3 pigs were sham-operated and served as controls. In macroscopical studies it was observed that in the pronounced pancreatitis cases the ligated duct was greatly dilated by a clear watery fluid. Only remnants of pale and firm grandular tissues were seen around the ectatic ducts. Microscopically, typical changes of chronic pancreatitis were noted. Complete disappearance of acini was followed by ductular cell proliferations. Glandular tissues were divided into lobuli by fibrotic tissues and fat cells. The wall of the main pancreatic duct was greatly thickened and fibrotic, presenting intensely proliferating ductular cells and round cell infiltrates. Furthermore, enlarged endocrine islets surrounded by connective tissue fibres were seen.
描述了主胰管手术结扎导致幼猪胰腺组织的形态学变化。对19只6至7周龄的动物进行手术，3周或6至8周后进行尸检。12头猪发生了明显的慢性胰腺炎并伴有完全外分泌功能不全。在7只未发生胰管扩张的动物中，2只因手术并发症死亡。此外，3头猪进行了假手术并作为对照。在宏观研究中观察到，在明显的胰腺炎病例中，结扎的导管被清澈的水样液体大大扩张。在扩张的导管周围仅可见苍白坚实的腺组织残余。显微镜下，可见慢性胰腺炎的典型变化。腺泡完全消失后，导管细胞增殖。腺组织被纤维组织和脂肪细胞分成小叶。主胰管壁明显增厚并纤维化，可见强烈增殖的导管细胞和圆形细胞浸润。此外，还可见被结缔组织纤维包围的增大的胰岛。
