Department of Medicine II Hokkaido University Graduate School of Medicine Sapporo Japan.
Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine Sapporo Japan.
J Diabetes Investig. 2013 May 6;4(3):326-9. doi: 10.1111/jdi.12040. Epub 2013 Feb 13.
AIMS/INTRODUCTION: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder including polycystic ovary morphology (PCOM), ovulatory dysfunction and hyperandrogenism. PCOS is frequently associated with type 2 diabetes mellitus; however, it is unknown whether PCOM and PCOS are prevalent in Japanese patients with type 1 diabetes mellitus. The purpose of our study was to determine the frequency of PCOM and PCOS in women with type 1 diabetes mellitus.
We evaluated clinical, hormonal and ovarian ultrasound data from 21 type 1 diabetes mellitus patients whose average glycated hemoglobin levels were 7.9 ± 1.5%.
Ultrasound identified PCOM in 11 patients (52.4%) and these patients also had higher levels of the androgen dehydroepiandrosterone sulfate (DHEA-S) than those without PCOM (P < 0.05). Of the patients with PCOM, five presented menstrual irregularities (45.5%) and three met the Japanese criteria for PCOS (27.2%); whereas all patients without PCOM had a normal menstrual cycle (P < 0.05).
Japanese premenopausal women with type 1 diabetes mellitus had a high frequency of PCOM as well as PCOS. This is the first research of this area carried out in an Asian population.
目的/引言：多囊卵巢综合征（PCOS）是一种异质性疾病，包括多囊卵巢形态（PCOM）、排卵功能障碍和高雄激素血症。PCOS 常与 2 型糖尿病相关；然而，目前尚不清楚 PCOM 和 PCOS 是否在日本 1 型糖尿病患者中普遍存在。本研究的目的是确定 1 型糖尿病女性中 PCOM 和 PCOS 的发生率。
我们评估了 21 例 1 型糖尿病患者的临床、激素和卵巢超声数据，这些患者的平均糖化血红蛋白水平为 7.9±1.5%。
超声在 11 例患者（52.4%）中发现了 PCOM，这些患者的雄激素去氢表雄酮硫酸酯（DHEA-S）水平也高于无 PCOM 的患者（P<0.05）。在患有 PCOM 的患者中，有 5 例出现月经不规律（45.5%），3 例符合日本 PCOS 标准（27.2%）；而所有无 PCOM 的患者均有正常的月经周期（P<0.05）。
日本绝经前 1 型糖尿病女性 PCOM 和 PCOS 的发生率较高。这是该领域在亚洲人群中的首次研究。
