接受持续性非卧床腹膜透析的儿童的低丙种球蛋白血症
Hypogammaglobulinemia in children undergoing continuous ambulatory peritoneal dialysis.
作者信息
Fivush B A, Case B, May M W, Lederman H M
机构信息
Department of Pediatrics, John Hopkins University School of Medicine, Baltimore, MD 21205.
出版信息
Pediatr Nephrol. 1989 Apr;3(2):186-8. doi: 10.1007/BF00852907.
Humoral immunity was evaluated in seven children undergoing continuous ambulatory peritoneal dialysis (CAPD). Five children (71%) had serum immunoglobulin levels which were more than 2 SD below the mean for age. One mechanism contributing to hypogammaglobulinemia was loss via the peritoneal membrane. Daily losses of IgG into peritoneal dialysis effluents represented 7%-29% of normal daily IgG synthesis, and losses increased with duration of CAPD therapy. Despite the observed hypogammaglobulinemia, all children had protective antibody responses to immunization.
对7名接受持续性非卧床腹膜透析（CAPD）的儿童进行了体液免疫评估。5名儿童（71%）的血清免疫球蛋白水平比同年龄组均值低2个标准差以上。导致低丙种球蛋白血症的一种机制是通过腹膜丢失。每日腹膜透析流出液中IgG的丢失量占正常每日IgG合成量的7%-29%，且随着CAPD治疗时间的延长，丢失量增加。尽管观察到存在低丙种球蛋白血症，但所有儿童对免疫接种均有保护性抗体反应。
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