Kidney Int. 1985 Mar;27(3):558-64. doi: 10.1038/ki.1985.47.
Continuous ambulatory peritoneal dialysis (CAPD) and continuous cycling peritoneal dialysis (CCPD) have become acceptable methods of treatment for children with endstage renal disease (ESRD). In this study we have compared the effectiveness of these two modalities of prolonged dwell peritoneal dialysis in 82 children treated at home with CAPD and/or CCPD for a mean of 10.2 months. Forty variables were evaluated during 92 patient periods (63 CAPD, 29 CCPD). There was no difference between the two groups with regard to sex, race, original disease, duration of dialysis, or volume of dialysis fluid. The only difference in biochemical profiles between the two groups was a higher serum creatinine in CCPD patients due in part to this group's greater age. The rate of peritonitis was not different (CAPD 1/4.6, CCPD 1/5.2 months), but the number of patient periods devoid of peritonitis was greater in the CCPD group (14/29 vs. 17/63, P = 0.04). Growth velocity index (GVI) and standard deviation scores (SD scores) were used to evaluate growth in the total group and subsets according to age. Overall GVI was 88% of expected and did not differ between PD groups (CAPD 88% vs. CCPD 89%). There were no significant changes in SD scores for growth during the course of prolonged dwell peritoneal dialysis indicating that the children did not experience further deterioration in growth. Children less than 4 years of age also did not have significant changes in SD scores. We conclude that CAPD and CCPD provide acceptable and comparable modes of dialytic therapy for children with ESRD.
持续非卧床腹膜透析（CAPD）和持续循环腹膜透析（CCPD）已成为终末期肾病（ESRD）患儿可接受的治疗方法。在本研究中，我们比较了这两种长时间留存腹膜透析方式对82例在家接受CAPD和/或CCPD治疗的患儿的有效性，这些患儿平均治疗时间为10.2个月。在92个患者治疗期（63个CAPD治疗期，29个CCPD治疗期）内评估了40个变量。两组在性别、种族、原发病、透析时间或透析液量方面没有差异。两组生化指标的唯一差异是CCPD患者的血清肌酐较高，部分原因是该组患儿年龄较大。腹膜炎发生率没有差异（CAPD为1/4.6，CCPD为1/5.2个月），但CCPD组无腹膜炎的患者治疗期数量更多（14/29对17/63，P = 0.04）。生长速度指数（GVI）和标准差评分（SD评分）用于评估整个研究组及按年龄划分的亚组的生长情况。总体GVI为预期值的88%，腹膜透析组之间没有差异（CAPD为88%，CCPD为89%）。在长时间留存腹膜透析过程中，生长的SD评分没有显著变化，这表明患儿的生长没有进一步恶化。4岁以下的儿童生长的SD评分也没有显著变化。我们得出结论，CAPD和CCPD为ESRD患儿提供了可接受且相当的透析治疗方式。
