Lawson M J, Butler R N, Goland G J, Jarrett I G, Roberts-Thomson I C, Partick E J, Dreosti I E
Department of Gastroenterology, Queen Elizabeth Hospital, Woodville SA, Australia.
Biol Trace Elem Res. 1988 Dec;18:115-21. doi: 10.1007/BF02917495.
As zinc status may influence susceptibility to colon cancer, we examined the effect of dietary zinc deficiency on the proliferation of epithelial cells (colonocytes) in the large bowel of rats. When compared to feed-restricted rats, those with zinc deficiency showed a significant reduction in proliferation in the distal colon as assessed by accumulated metaphase arrest and crypt cell production rates in vivo. Zinc deficiency had no apparent effect on thymidine kinase activity in colonocytes but was accompanied by minor changes in fecal mass and fecal pH. In rats, zinc deficiency is associated with a reduction in the rate of proliferation of colonocytes in the distal colon.
由于锌状态可能影响结肠癌易感性，我们研究了膳食锌缺乏对大鼠大肠上皮细胞（结肠细胞）增殖的影响。与限食大鼠相比，通过体内累积中期阻滞和隐窝细胞产生率评估，锌缺乏大鼠的远端结肠增殖显著降低。锌缺乏对结肠细胞中的胸苷激酶活性无明显影响，但伴有粪便量和粪便pH值的轻微变化。在大鼠中，锌缺乏与远端结肠结肠细胞增殖率降低有关。
