ASL Salerno, Mental Health Centre Cava de' Tirreni - Vietri Sul Mare, Department of Mental Health , Piazza Galdi, 841013 Cava de' Tirreni, Salerno , Italy +39 089 4455439 ; +39 089 4455440 ;
Expert Opin Drug Saf. 2014 Jun;13(6):735-44. doi: 10.1517/14740338.2014.908849.
Anxiety disorders are relatively common psychiatric illnesses in children and adolescents. In young people, such disorders are likely to show severe outcomes and adversely impact on multiple aspects of personality and social integration.
This article aims to analyze systematically the efficacy of both old- and new-generation antidepressants in children and adolescents diagnosed with non-obsessive-compulsive disorder anxiety disorders.
Reviewed data demonstrate that social phobia is the only pediatric anxiety disorder whose response to antidepressant medications has been investigated in an adequate number of studies. In this clinical condition, venlafaxine and fluoxetine (and fluvoxamine as second choice) are the only antidepressants that have shown convincing reports on efficacy. In contrast, apart from preliminary observations suggesting the efficacy of sertraline in pediatric generalized anxiety disorder, no evidence-based information definitively supports the use of antidepressants for managing other juvenile anxiety disorders.
焦虑障碍在儿童和青少年中是相对常见的精神疾病。在年轻人中，这些障碍可能表现出严重的后果，并对个性和社会融合的多个方面产生不利影响。
本文旨在系统分析旧一代和新一代抗抑郁药在诊断为非强迫症焦虑障碍的儿童和青少年中的疗效。
综述数据表明，社交恐惧症是唯一一种已经在足够多的研究中调查了抗抑郁药物反应的儿童焦虑障碍。在这种临床情况下，文拉法辛和氟西汀（氟伏沙明作为第二选择）是唯一显示出疗效令人信服的抗抑郁药。相比之下，除了初步观察提示舍曲林在儿童广泛性焦虑症中的疗效外，没有基于证据的信息明确支持使用抗抑郁药来治疗其他青少年焦虑障碍。
