Nguyen Mai Lin, Willows Brooke, Khan Rihan, Chi Alexander, Kim Lyndon, Nour Sherif G, Sroka Thomas, Kerr Christine, Godinez Juan, Mills Melissa, Karlsson Ulf, Altdorfer Gabor, Nguyen Nam Phong, Jendrasiak Gordon
Department of Psychology, Stanford University , Palo Alto, CA , USA.
School of Medicine, University of Arizona , Phoenix, AZ , USA.
Front Oncol. 2014 May 5;4:91. doi: 10.3389/fonc.2014.00091. eCollection 2014.
Magnetic resonance spectroscopy (MRS) is a non-invasive technique to detect metabolites within the normal and tumoral tissues. The ability of MRS to diagnose areas of high metabolic activity linked to tumor cell proliferation is particularly useful for radiotherapy treatment planning because of better gross tumor volume (GTV) delineation. The GTV may be targeted with higher radiation dose, potentially improving local control without excessive irradiation to the normal adjacent tissues. Prostate cancer and glioblastoma multiforme (GBM) are two tumor models that are associated with a heterogeneous tumor distribution. Preliminary studies suggest that the integration of MRS into radiotherapy planning for these tumors is feasible and safe. Image-guided radiotherapy (IGRT) by virtue of daily tumor imaging and steep dose gradient may allow for tumor dose escalation with the simultaneous integrated boost technique (SIB) and potentially decrease the complications rates in patients with GBM and prostate cancers.
磁共振波谱（MRS）是一种用于检测正常组织和肿瘤组织内代谢物的非侵入性技术。由于能更好地勾勒大体肿瘤体积（GTV），MRS诊断与肿瘤细胞增殖相关的高代谢活性区域的能力对于放射治疗计划尤为有用。GTV可接受更高的辐射剂量，有可能在不过度照射相邻正常组织的情况下改善局部控制。前列腺癌和多形性胶质母细胞瘤（GBM）是两种与肿瘤分布不均相关的肿瘤模型。初步研究表明，将MRS纳入这些肿瘤的放射治疗计划是可行且安全的。借助每日肿瘤成像和陡峭剂量梯度的图像引导放射治疗（IGRT），可通过同步整合加量技术（SIB）提高肿瘤剂量，并有可能降低GBM和前列腺癌患者的并发症发生率。
