Gökmen Ferhat, Akbal Ayla, Reşorlu Hatice, Gökmen Esra, Güven Mustafa, Aras Adem Bozkurt, Erbağ Gökhan, Kömürcü Erkam, Akbal Erdem, Coşar Murat
Canakkale Onsekiz Mart University, Canakkale, Turkey.
Canakkale State Hospital, Canakkale, Turkey.
J Clin Lab Anal. 2015 Jul;29(4):294-8. doi: 10.1002/jcla.21768. Epub 2014 May 21.
In recent years, white blood cells (WBCs) and their subtypes have been studied in relation to inflammation. The aim of our study was to assess the relationship between neutrophil-lymphocyte ratio (NLR) and ankylosing spondylitis (AS).
We enrolled a total of 177 patients, 96 AS and 81 healthy controls. Complete blood count, WBC, neutrophil and lymphocyte levels were measured, and the NLR was calculated. In the assessment of AS, we used the erythrocyte sedimentation rate, C-reactive protein (CRP), the Bath Ankylosing Spondylitis Disease Activity Index, and the Bath Ankylosing Spondylitis Functional Index.
In the present study, 96 AS and 81 healthy individuals were enrolled. The mean age was 43.8 ± 12.9 and 46.5 ± 11.2 years, respectively. Mean disease duration of AS patients was 6.9 ± 5.6 years (median = 5, min-max = 1-25). The patients with AS had a higher NLR than the control individuals (mean NLR, 2.24 ± 1.23 and 1.73 ± 0.70, respectively, P < 0.001). A statistically significant positive correlation was observed between NLR and CRP (r = 0.322, P = 0.01). The patients receiving antitumor necrosis factor α therapy had a lower NLR than the patients receiving nonsteroidal anti-inflammatory drug therapy (mean NLR, 1.71 ± 0.62 and 2.41 ± 1.33, respectively, P = 0.02).
NLR may be seen as a useful marker for demonstrating inflammation together with acute phase reactants such as CRP and in evaluating the effectiveness of anti-TNF-α therapy.
近年来，白细胞（WBCs）及其亚型已被用于炎症相关研究。我们研究的目的是评估中性粒细胞与淋巴细胞比值（NLR）和强直性脊柱炎（AS）之间的关系。
我们共纳入了177例患者，其中96例AS患者和81例健康对照。测量全血细胞计数、白细胞、中性粒细胞和淋巴细胞水平，并计算NLR。在评估AS时，我们使用了红细胞沉降率、C反应蛋白（CRP）、巴斯强直性脊柱炎疾病活动指数和巴斯强直性脊柱炎功能指数。
在本研究中，纳入了96例AS患者和81例健康个体。平均年龄分别为43.8±12.9岁和46.5±11.2岁。AS患者的平均病程为6.9±5.6年（中位数=5，最小值-最大值=1-25）。AS患者的NLR高于对照个体（平均NLR分别为2.24±1.23和1.73±0.70，P<0.001）。观察到NLR与CRP之间存在统计学显著正相关（r=0.322，P=0.01）。接受抗肿瘤坏死因子α治疗的患者的NLR低于接受非甾体抗炎药治疗的患者（平均NLR分别为1.71±0.62和2.41±1.33，P=0.02）。
NLR可被视为一种有用的标志物，与CRP等急性期反应物一起用于显示炎症，并评估抗TNF-α治疗的有效性。
