负载银纳米颗粒的海藻酸钙珠嵌入明胶支架的制备与表征
Preparation and characterization of silver nanoparticles-loaded calcium alginate beads embedded in gelatin scaffolds.
作者信息
Pankongadisak Porntipa, Ruktanonchai Uracha Rungsardthong, Supaphol Pitt, Suwantong Orawan
机构信息
School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai, 57100, Thailand.
出版信息
AAPS PharmSciTech. 2014 Oct;15(5):1105-15. doi: 10.1208/s12249-014-0140-9. Epub 2014 May 23.
Abstract
Silver nanoparticles (AgNPs)-loaded alginate beads embedded in gelatin scaffolds were successfully prepared. The AgNPs-loaded calcium alginate beads were prepared by electrospraying method. The effect of alginate concentration and applied voltage on shape and diameter of beads was studied. The diameter of dry AgNPs-loaded calcium alignate beads at various concentrations of AgNO3 ranged between 154 and 171 μm. The AgNPs-loaded calcium alginate beads embedded in gelatin scaffolds were fabricated by freeze-drying method. The water swelling and weight loss behaviors of the AgNPs-loaded alginate beads embedded in gelatin scaffolds increased with an increase in the submersion time. Moreover, the genipin-cross-linked gelatin scaffolds were proven to be nontoxic to normal human dermal fibroblasts, suggesting their potential uses as wound dressings.
摘要
成功制备了嵌入明胶支架中的载银纳米颗粒（AgNPs）海藻酸盐珠。通过电喷雾法制备了载AgNPs的海藻酸钙珠。研究了海藻酸盐浓度和施加电压对珠形状和直径的影响。在不同浓度的AgNO3下，干燥的载AgNPs海藻酸钙珠的直径在154至171μm之间。通过冷冻干燥法制备了嵌入明胶支架中的载AgNPs海藻酸钙珠。嵌入明胶支架中的载AgNPs海藻酸盐珠的水溶胀和失重行为随浸没时间的增加而增加。此外，已证明京尼平交联的明胶支架对正常人皮肤成纤维细胞无毒，表明它们作为伤口敷料的潜在用途。
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