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副干酪乳杆菌CNCM I-4034、短双歧杆菌CNCM I-4035和鼠李糖乳杆菌CNCM I-4036对Zucker大鼠肝脂肪变性的影响。

Effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 on hepatic steatosis in Zucker rats.

作者信息

Plaza-Diaz Julio, Gomez-Llorente Carolina, Abadia-Molina Francisco, Saez-Lara Maria Jose, Campaña-Martin Laura, Muñoz-Quezada Sergio, Romero Fernando, Gil Angel, Fontana Luis

机构信息

Department of Biochemistry & Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain; Institute of Nutrition & Food Technology "José Mataix", Biomedical Research Center, University of Granada, Granada, Spain.

Department of Cell Biology, School of Sciences, University of Granada, Granada, Spain.

出版信息

PLoS One. 2014 May 22;9(5):e98401. doi: 10.1371/journal.pone.0098401. eCollection 2014.

DOI:10.1371/journal.pone.0098401
PMID:24852284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4031175/
Abstract

We have previously described the safety and immunomodulatory effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 in healthy volunteers. The scope of this work was to evaluate the effects of these probiotic strains on the hepatic steatosis of obese rats. We used the Zucker rat as a genetic model of obesity. Zucker-Lepr(fa/fa) rats received one of three probiotic strains, a mixture of L. paracasei CNCM I-4034 and B. breve CNCM I-4035, or a placebo for 30 days. An additional group of Zucker-lean+/fa rats received a placebo for 30 days. No alterations in intestinal histology, in the epithelial, lamina propria, muscular layers of the ileal or colonic mucosa, or the submucosae, were observed in any of the experimental groups. Triacylglycerol content decreased in the liver of Zucker-Lepr(fa/fa) rats that were fed L. rhamnosus, B. breve, or the mixture of B. breve and L. paracasei. Likewise, the area corresponding to neutral lipids was significantly smaller in the liver of all four groups of Zucker-Lepr(fa/fa) rats that received probiotics than in rats fed the placebo. Zucker-Lepr(fa/fa) rats exhibited significantly greater serum LPS levels than Zucker-lean+/fa rats upon administration of placebo for 30 days. In contrast, all four groups of obese Zucker-Lepr(fa/fa) rats that received LAB strains exhibited serum LPS concentrations similar to those of Zucker-lean+/fa rats. Serum TNF-α levels decreased in the Zucker-Lepr(fa/fa) rats that received B. breve, L. rhamnosus, or the mixture, whereas L. paracasei feeding decreased IL-6 levels in the serum of Zucker-Lepr(fa/fa) rats. In conclusion, the probiotic strains reduced hepatic steatosis in part by lowering serum LPS, and had an anti-inflammatory effect in obese Zucker rats.

摘要

我们之前已经描述了副干酪乳杆菌CNCM I-4034、短双歧杆菌CNCM I-4035和鼠李糖乳杆菌CNCM I-4036在健康志愿者体内的安全性和免疫调节作用。这项工作的范围是评估这些益生菌菌株对肥胖大鼠肝脂肪变性的影响。我们使用 Zucker 大鼠作为肥胖的遗传模型。Zucker-Lepr(fa/fa)大鼠接受三种益生菌菌株之一、副干酪乳杆菌CNCM I-4034和短双歧杆菌CNCM I-4035的混合物或安慰剂，持续30天。另一组Zucker-lean+/fa大鼠接受安慰剂30天。在任何实验组中，均未观察到肠道组织学、回肠或结肠黏膜的上皮、固有层、肌层或黏膜下层有改变。喂食鼠李糖乳杆菌、短双歧杆菌或短双歧杆菌与副干酪乳杆菌混合物的Zucker-Lepr(fa/fa)大鼠肝脏中的三酰甘油含量降低。同样，接受益生菌的所有四组Zucker-Lepr(fa/fa)大鼠肝脏中对应中性脂质的面积明显小于喂食安慰剂的大鼠。在给予安慰剂30天后，Zucker-Lepr(fa/fa)大鼠的血清LPS水平显著高于Zucker-lean+/fa大鼠。相比之下，接受LAB菌株的所有四组肥胖Zucker-Lepr(fa/fa)大鼠的血清LPS浓度与Zucker-lean+/fa大鼠相似。接受短双歧杆菌、鼠李糖乳杆菌或混合物的Zucker-Lepr(fa/fa)大鼠血清TNF-α水平降低，而喂食副干酪乳杆菌可降低Zucker-Lepr(fa/fa)大鼠血清中的IL-6水平。总之，益生菌菌株部分通过降低血清LPS减少肝脂肪变性，并对肥胖的Zucker大鼠具有抗炎作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f36a/4031175/c7cf3538aec3/pone.0098401.g006.jpg
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