G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russian Federation.
J Nat Prod. 2014 Jun 27;77(6):1390-5. doi: 10.1021/np500151b. Epub 2014 May 22.
Ten new austalide meroterpenoids (1-10) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The absolute configurations of some of the metabolites were assigned by the modified Mosher's method and CD data. Compounds 1, 2, 8, and 9 were able to inhibit AP-1-dependent transcriptional activity in JB6 Cl41 cell lines at noncytotoxic concentrations. Austalides 1-5, 8, and 9 exhibited significant inhibitory activity against endo-1,3-β-D-glucanase from a crystalline stalk of the marine mollusk Pseudocardium sachalinensis.
从藻类来源的真菌 Penicillium thomii KMM 4645 和 Penicillium lividum KMM 4663 中分离得到了 10 种新型 austalide 混合萜类化合物（1-10）。通过广泛的光谱分析以及与相关已知化合物的比较，确定了它们的结构。通过改进的 Mosher 法和 CD 数据确定了一些代谢物的绝对构型。在非细胞毒性浓度下，化合物 1、2、8 和 9 能够抑制 JB6 Cl41 细胞系中 AP-1 依赖性转录活性。austalides 1-5、8 和 9 对来自海洋软体动物 Pseudocardium sachalinensis 的结晶茎中的内-1,3-β-D-葡聚糖酶表现出显著的抑制活性。
