来自海藻衍生真菌特异青霉和淡紫青霉的马尾藻缩酚酸肽A-G，6,6-螺缩酮类化合物
Sargassopenillines A-G, 6,6-spiroketals from the alga-derived fungi Penicillium thomii and Penicillium lividum.
作者信息
Zhuravleva Olesya I, Sobolevskaya Maria P, Afiyatullov Shamil Sh, Kirichuk Natalya N, Denisenko Vladimir A, Dmitrenok Pavel S, Yurchenko Ekaterina A, Dyshlovoy Sergey A
机构信息
Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia.
出版信息
Mar Drugs. 2014 Dec 9;12(12):5930-43. doi: 10.3390/md12125930.
Seven new 6,6-spiroketals, sargassopenillines A-G (1-7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher's method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC50 value of 15 µM.
从海藻来源的真菌特异青霉KMM 4645和暗绿青霉KMM 4663中分离出7个新的6,6-螺缩酮类化合物，即马尾藻青霉素A-G（1-7）。这些代谢产物的结构通过高分辨质谱以及一维和二维核磁共振波谱确定。化合物1、5和6的绝对构型通过改良的莫舍尔方法和圆二色光谱数据确定。马尾藻青霉素C（3）抑制致癌核因子AP-1的转录活性，IC50值为15 μM。
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