Cushman P, Escobar M
Medical College of Virginia.
J Subst Abuse. 1989;1(4):461-5.
Male heterosexual i.v. drug abusers in methadone maintenance treatment were surveyed for HIV disease and followed prospectively in Richmond, Virginia. Five of 50 (10%) had both positive ELISA and Western Blot antibodies initially, although none had other clinical manifestations. Forty-two (84%) were restudied 1 year later. None had developed clinical manifestations of HIV disease, or seroconverted from negative to positive. Thirty-nine Control i.v. drug abusers seeking methadone or inpatient detoxification showed a similar low seropositivity rate (3%), indicating that Richmond had low endemicity for HIV during the year. An unexpected finding in the followup of the 5 with initial seropositivity was that only 1 retained both ELISA and Western Blot positivity. The difference in serological reaction was unexplained.
在弗吉尼亚州里士满，对接受美沙酮维持治疗的男性异性静脉注射吸毒者进行了艾滋病病毒疾病调查，并对他们进行了前瞻性跟踪。50名患者中有5名（10%）最初酶联免疫吸附测定（ELISA）和免疫印迹法检测抗体均呈阳性，不过均无其他临床表现。一年后对其中42名（84%）患者进行了复查。无人出现艾滋病病毒疾病的临床表现，也无人血清学由阴性转为阳性。39名寻求美沙酮或住院戒毒的对照静脉注射吸毒者血清阳性率同样较低（3%），表明该年里士满艾滋病病毒的地方流行率较低。对最初血清呈阳性的5名患者进行随访时，一个意外发现是只有1人酶联免疫吸附测定和免疫印迹法检测仍为阳性。血清学反应的差异无法解释。
