颈动脉钙化与深部脑微出血有关。
Carotid artery calcification is associated with deep cerebral microbleeds.
作者信息
Chung Pil-Wook, Park Kwang-Yeol, Kim Jeong-Min, Shin Dong-Woo, Ha Sam-Yeol
机构信息
Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
出版信息
Eur Neurol. 2014;72(1-2):60-3. doi: 10.1159/000358513. Epub 2014 May 21.
BACKGROUND/AIMS: The aim of the present study was to determine the association between arterial calcification and cerebral microbleeds (CMB) relative to their distribution.
METHODS
We identified 834 consecutive patients with acute ischemic stroke or transient ischemic attack who underwent CT angiography and susceptibility-weighted imaging.
RESULTS
Internal carotid artery (ICA) calcification and CMB were found in 660 patients (79.1%) and 335 patients (40.2%), respectively. ICA calcification was independently associated with CMB of any location (odds ratio, OR, 2.86, 95% CI 2.01-4.08, p < 0.0001). The association between calcification and deep CMB was stronger (OR 3.51, 95% CI 2.39-5.14, p < 0.0001). However, ICA calcification was not associated with CMB in a strictly lobar area.
CONCLUSION
ICA calcification is an independent risk factor for deep CMB but not for a strictly lobar CMB. Our findings might contribute to the elucidation of the pathogenesis of cerebral small vessel disease.
背景/目的：本研究旨在确定动脉钙化与脑微出血（CMB）之间的关联及其分布情况。
方法
我们纳入了834例连续的急性缺血性卒中或短暂性脑缺血发作患者，这些患者均接受了CT血管造影和磁敏感加权成像检查。
结果
分别在660例患者（79.1%）中发现颈内动脉（ICA）钙化，在335例患者（40.2%）中发现CMB。ICA钙化与任何部位的CMB均独立相关（比值比，OR，2.86，95%可信区间2.01 - 4.08，p < 0.0001）。钙化与深部CMB的关联更强（OR 3.51，95%可信区间2.39 - 5.14，p < 0.0001）。然而，ICA钙化与严格局限于脑叶区域的CMB无关。
结论
ICA钙化是深部CMB的独立危险因素，但不是严格局限于脑叶CMB的危险因素。我们的研究结果可能有助于阐明脑小血管病的发病机制。
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