Harper Kristin N, Liu Xinhua, Hall Megan N, Ilievski Vesna, Oka Julie, Calancie Larissa, Slavkovich Vesna, Levy Diane, Siddique Abu, Alam Shafiul, Mey Jacob L, van Geen Alexander, Graziano Joseph H, Gamble Mary V
From the Departments of Environmental Health Sciences (Dr Harper, Ms Ilievski, Ms Oka, Ms Calancie, Ms Slavkovich, Dr Graziano, and Dr Gamble), Biostatistics (Dr Liu and Ms Levy), and Epidemiology (Dr Hall), Mailman School of Public Health, Columbia University, New York, NY; Columbia University Arsenic Project in Bangladesh (Mr Siddique and Mr Alam), Dhaka, Bangladesh; Lamont-Doherty Earth Observatory (Dr Mey and Dr van Geen), Columbia University, Palisades, NY; and Kingsbridge Community College (Dr Mey), New York, NY.
J Occup Environ Med. 2014 Jun;56(6):652-8. doi: 10.1097/JOM.0000000000000166.
To evaluate the dose-response relationship between arsenic (As) exposure and markers of oxidative damage in Bangladeshi adults.
We recruited 378 participants drinking water from wells assigned to five water As exposure categories; the distribution of subjects was as follows: (1) less than 10 μg/L (n=76); (2) 10 to 100 μg/L (n=104); (3) 101 to 200 μg/L (n=86); (4) 201 to 300 μg/L (n=67); and (5) more than 300 μg/L (n=45). Arsenic concentrations were measured in well water, as well as in urine and blood. Urinary 8-oxo-2'-deoxyguanosine and plasma protein carbonyls were measured to assess oxidative damage.
None of our measures of As exposure were significantly associated with protein carbonyl or 8-oxo-2'-deoxyguanosine levels.
We found no evidence to support a significant relationship between long-term exposure to As-contaminated drinking water and biomarkers of oxidative damage among Bangladeshi adults.
评估孟加拉国成年人砷（As）暴露与氧化损伤标志物之间的剂量反应关系。
我们招募了378名从分配到五个水砷暴露类别的水井中取水饮用的参与者；受试者分布如下：（1）低于10μg/L（n = 76）；（2）10至100μg/L（n = 104）；（3）101至200μg/L（n = 86）；（4）201至300μg/L（n = 67）；以及（5）高于300μg/L（n = 45）。测量了井水、尿液和血液中的砷浓度。测量尿8-氧代-2'-脱氧鸟苷和血浆蛋白羰基以评估氧化损伤。
我们的砷暴露测量指标均与蛋白羰基或8-氧代-2'-脱氧鸟苷水平无显著关联。
我们没有发现证据支持长期暴露于受砷污染的饮用水与孟加拉国成年人氧化损伤生物标志物之间存在显著关系。
