de Boer Michiel P, Wijnstok Nienke J, Serné Erik H, Eringa Etto C, Stehouwer Coen D A, Flyvbjerg Allan, Hoekstra Trynke, Heymans Martijn W, Meijer Rick I, Twisk Jos W, Smulders Yvo M
Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands; Institute for Cardiovascular Research - ICaR-VU, VU University Medical Center, Amsterdam, the Netherlands.
Eur J Clin Invest. 2014 Jul;44(7):660-7. doi: 10.1111/eci.12284.
obesity-related microvascular dysfunction, including alterations in rhythmic changes in vascular diameter, so-called 'vasomotion', may be important in the clustering of obesity with other cardiovascular risk factors. Adipokines have been suggested to play a role in obesity-related vascular dysfunction. Alterations in vasomotion have been found using extreme body mass index (BMI) phenotypes. Whether these alterations can be translated to the general population is unknown. The aim was to retrospectively investigate relationships between BMI, vasomotion and adipokines in a population-based cohort.
Adiposity, vasomotion, adiponectin and leptin were determined in 94 apparently healthy participants (age 42 years, 46 men, mean BMI 25·5 ± 3·8 kg/m(2) ) of the Amsterdam Growth and Health Longitudinal Study (AGHLS). Vasomotion was assessed via wavelet analysis of skin laser Doppler flowmetry (LDF).
BMI was associated with the neurogenic domain of the vasomotion spectrum (β -0·011, P = 0·046), adiponectin (β -0·18, P = 0·028) and leptin (β 2·22, P < 0·0001). Adiponectin was positively associated with the neurogenic domain of vasomotion (β 0·016, P = 0·019). Leptin did not show any significant relationship with vasomotion. The association between BMI and the neurogenic domain of the vasomotion spectrum was partly explained by adiponectin.
The association between adiposity and microvascular vasomotion also applies to the normal population and is partly explained by adiponectin.
肥胖相关的微血管功能障碍，包括血管直径的节律性变化（即所谓的“血管运动”）改变，可能在肥胖与其他心血管危险因素的聚集过程中起重要作用。脂肪因子被认为在肥胖相关的血管功能障碍中发挥作用。使用极端体重指数（BMI）表型已发现血管运动存在改变。但这些改变是否能推广到普通人群尚不清楚。本研究旨在对一个基于人群的队列中BMI、血管运动和脂肪因子之间的关系进行回顾性调查。
在阿姆斯特丹生长与健康纵向研究（AGHLS）的94名明显健康的参与者（年龄42岁，46名男性，平均BMI 25.5±3.8kg/m²）中测定肥胖程度、血管运动、脂联素和瘦素。通过皮肤激光多普勒血流仪（LDF）的小波分析评估血管运动。
BMI与血管运动频谱的神经源性区域（β -0.011，P = 0.046）、脂联素（β -0.18，P = 0.028）和瘦素（β 2.22，P < 0.0001）相关。脂联素与血管运动的神经源性区域呈正相关（β 0.016，P = 0.019）。瘦素与血管运动未显示出任何显著关系。BMI与血管运动频谱的神经源性区域之间的关联部分由脂联素解释。
肥胖与微血管血管运动之间的关联也适用于正常人群，且部分由脂联素解释。
