Casalegno Jean-Sebastien, Huissoud Cyril, Rudigoz Rene, Massardier Jerome, Gaucherand Pascal, Mekki Yahia
Laboratory of Virology, Hospices Civils de Lyon, Lyon, France.
Department of Gynecology and Obstetrics, Hospices Civils de Lyon, Lyon, France.
Int J Gynaecol Obstet. 2014 Sep;126(3):248-51. doi: 10.1016/j.ijgo.2014.03.021. Epub 2014 May 2.
To identify women who had measles while being pregnant during the 2011 epidemic peak in Lyon, France, and to document maternal characteristics and fetal outcomes.
In a retrospective survey, women who had measles while being pregnant between January and December 2011 were identified from the records of the Laboratory of Virology, Hospices Civils de Lyon. Epidemiologic data, clinical characteristics, and measles outcomes were assessed.
In total, 11 pregnant women and 2 women who had just delivered were hospitalized with measles infection in Lyon. The most severe maternal complication was pneumonia, which occurred in 4 women (30.8%). Other maternal complications included fever (11 women; 84.6%) and elevated liver enzymes (2/6 women; 33.3%). All women delivered healthy newborns. Post-exposure prophylaxis using human polyvalent immunoglobulin was initiated for three newborns whose mothers acquired measles in the immediate postpartum period. None of these newborns subsequently acquired measles, although breastfeeding was maintained.
Although measles infections during pregnancy can have a deleterious effect on both mother and child, in many cases hospitalization is not required. Unnecessary admission should be avoided given the high risk of transmission of measles in an obstetrics ward.
确定在法国里昂2011年麻疹流行高峰期期间怀孕时感染麻疹的女性，并记录产妇特征和胎儿结局。
在一项回顾性调查中，从里昂市立医院病毒学实验室的记录中识别出2011年1月至12月期间怀孕时感染麻疹的女性。评估了流行病学数据、临床特征和麻疹结局。
在里昂，共有11名孕妇和2名刚分娩的女性因麻疹感染住院。最严重的产妇并发症是肺炎，4名女性（30.8%）出现该并发症。其他产妇并发症包括发热（11名女性；84.6%）和肝酶升高（2/6名女性；33.3%）。所有女性均分娩出健康的新生儿。对3名母亲在产后立即感染麻疹的新生儿进行了人多价免疫球蛋白暴露后预防。尽管维持了母乳喂养，但这些新生儿随后均未感染麻疹。
尽管孕期麻疹感染可能对母婴均产生有害影响，但在许多情况下无需住院治疗。鉴于产科病房麻疹传播风险高，应避免不必要的入院。
