Pappo Alberto S
From the Solid Tumor Division, St. Jude Children's Research Hospital, Memphis, TN.
Am Soc Clin Oncol Educ Book. 2014:e432-5. doi: 10.14694/EdBook_AM.2014.34.e432.
Pediatric melanoma is rare and given the diagnostic challenges it presents in this age group, it is difficult to interpret the literature describing its natural history and outcome. Recent genomic analysis demonstrates that conventional melanoma in children and adolescents shares many of the genomic features that have been described in adult melanoma, including BRAF mutations. Thus, this patient group should be given the opportunity to enroll in National Cancer Institute and pharmaceutically sponsored trials that incorporate novel targeted agents.
儿童黑色素瘤很罕见，鉴于其在该年龄组中带来的诊断挑战，很难解读描述其自然病史和预后的文献。最近的基因组分析表明，儿童和青少年的传统黑色素瘤具有许多已在成人黑色素瘤中描述过的基因组特征，包括BRAF突变。因此，应该让这个患者群体有机会参加美国国立癌症研究所及制药公司赞助的、纳入新型靶向药物的试验。
