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Sentinel lymph node biopsy in histologically ambiguous melanocytic tumors with spitzoid features (so-called atypical spitzoid tumors).对具有Spitz样特征的组织学不明确的黑素细胞肿瘤（所谓的非典型Spitz样肿瘤）进行前哨淋巴结活检。
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Pediatr Dermatol. 2012 Jul-Aug;29(4):448-53. doi: 10.1111/j.1525-1470.2011.01699.x. Epub 2011 Dec 30.

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本文引用的文献

1
PD-L1 expression in melanocytic lesions does not correlate with the BRAF V600E mutation.黑色素细胞病变中的 PD-L1 表达与 BRAF V600E 突变无关。
Cancer Immunol Res. 2015 Feb;3(2):110-5. doi: 10.1158/2326-6066.CIR-14-0145. Epub 2014 Nov 4.
2
The genomic landscape of childhood and adolescent melanoma.儿童及青少年黑色素瘤的基因组格局。
J Invest Dermatol. 2015 Mar;135(3):816-823. doi: 10.1038/jid.2014.425. Epub 2014 Sep 30.
3
The immune escape in melanoma: role of the impaired dendritic cell function.黑色素瘤中的免疫逃逸：树突状细胞功能受损的作用。
Expert Rev Clin Immunol. 2014 Oct;10(10):1395-404. doi: 10.1586/1744666X.2014.955851. Epub 2014 Sep 2.
4
PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics.PD-L1 标记了一组具有较短总生存期和独特遗传及形态学特征的黑色素瘤。
Ann Oncol. 2014 Dec;25(12):2433-2442. doi: 10.1093/annonc/mdu452. Epub 2014 Sep 15.
5
The immune-related role of BRAF in melanoma.BRAF在黑色素瘤中的免疫相关作用。
Mol Oncol. 2015 Jan;9(1):93-104. doi: 10.1016/j.molonc.2014.07.014. Epub 2014 Aug 6.
6
Fluorescence in situ hybridization analysis of atypical melanocytic proliferations and melanoma in young patients.年轻患者非典型黑素细胞增生和黑色素瘤的荧光原位杂交分析
Pediatr Dermatol. 2014 Sep-Oct;31(5):561-9. doi: 10.1111/pde.12382. Epub 2014 Jun 13.
7
Understanding the biology of melanoma and therapeutic implications.了解黑色素瘤的生物学特性及其治疗意义。
Hematol Oncol Clin North Am. 2014 Jun;28(3):437-53. doi: 10.1016/j.hoc.2014.02.007.
8
Pediatric melanoma: the whole (genome) story.儿童黑色素瘤：完整（基因组）故事
Am Soc Clin Oncol Educ Book. 2014:e432-5. doi: 10.14694/EdBook_AM.2014.34.e432.
9
Melanoma, version 4.2014.黑素瘤，第 4 版，2014 年。
J Natl Compr Canc Netw. 2014 May;12(5):621-9. doi: 10.6004/jnccn.2014.0066.
10
Clinical and pathologic findings of Spitz nevi and atypical Spitz tumors with ALK fusions.ALK 融合相关性 Spitz 痣和不典型 Spitz 肿瘤的临床和病理特征。
Am J Surg Pathol. 2014 Jul;38(7):925-33. doi: 10.1097/PAS.0000000000000187.

儿童斯皮茨样黑色素瘤：病例系列报道及文献复习

Spitzoid melanoma of childhood: a case series and review.

作者信息

Batra Sandeep

机构信息

Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, 705 Riley Hospital Drive, Indianapolis, IN 46202, USA.

Division of Pediatric Hematology-Oncology, Indiana University School of Medicine, Riley Hospital for Children, 705 Riley Hospital Drive, Indianapolis, IN 46202, USA.

出版信息

Melanoma Manag. 2015 May;2(2):121-125. doi: 10.2217/mmt.15.6. Epub 2015 May 18.

DOI:10.2217/mmt.15.6
PMID:30190841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6094708/
Abstract

Spitzoid melanomas (SM) and atypical Spitz tumors (AST) are rare pediatric neoplasms. We performed a retrospective, single-institution review and report our institutional experience. We identified 10 patients (median age: 12.5 years). A sentinel node biopsy (SNB) was performed in 8/10 (80%) patients, and interestingly 7/8 (87.5%) were found to be positive for malignant cells. A complete regional lymphadenectomy was performed in all SNB-positive patients, but only 2/8 (25%) were found to have additional lymph node spread. Adjuvant therapy was administered in 5/8 SLNB-positive and 2/2 (100%) regional LN-positive cases. All patients had excellent long-term outcomes (100% survival). This report highlights the excellent outcomes associated with SNB + pediatric SM and AST.

摘要

斯皮茨样黑色素瘤（SM）和非典型斯皮茨肿瘤（AST）是罕见的儿科肿瘤。我们进行了一项回顾性单机构研究并报告我们机构的经验。我们确定了10例患者（中位年龄：12.5岁）。10例患者中有8例（80%）进行了前哨淋巴结活检（SNB），有趣的是，8例中有7例（87.5%）发现有恶性细胞阳性。所有SNB阳性患者均进行了完整的区域淋巴结清扫，但仅8例中的2例（25%）发现有额外的淋巴结转移。5例SNB阳性和2例（100%）区域淋巴结阳性病例接受了辅助治疗。所有患者均有出色的长期预后（100%存活）。本报告强调了SNB + 儿科SM和AST相关的出色预后。