Fondazione Santa Lucia, IRCCS, Laboratory of Neurophysiology, Rome, Italy; Istituto Serafico, Assisi, Perugia, Italy.
Fondazione Santa Lucia, IRCCS, Laboratory of Neurophysiology, Rome, Italy.
Exp Neurol. 2014 Nov;261:320-7. doi: 10.1016/j.expneurol.2014.05.010. Epub 2014 May 20.
We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and paired-pulse synaptic responses in the hippocampal CA1 neuronal population and prevented the reduction of spine density and dendrite branching of pyramidal neurons. These data demonstrate that EE exerts its therapeutic effect by normalizing multiple aspects of hippocampal function and provide experimental support for its use in the optimization of existent treatments.
我们分析了环境富集（EE）对易发性癫痫小鼠模型的影响，该模型中突触前蛋白 Bassoon 的遗传缺失导致海马区的结构和功能改变，并导致早期自发性癫痫发作，类似于人类神经发育障碍。从 P21 开始的为期一个月的 EE 可降低癫痫发作的严重程度，维持海马 CA1 神经元群体中的长时程增强（LTP）和成对脉冲突触反应，并防止锥体神经元的密度和树突分支减少。这些数据表明，EE 通过使海马区功能的多个方面正常化发挥其治疗作用，并为其在优化现有治疗方法中的应用提供了实验支持。
