Schmidt Heike, Cleeland Charles S, Bauer Alexander, Landenberger Margarete, Jahn Patrick
Institute for Health and Nursing Science, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Halle, Germany; The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA; Nursing Research Unit, University Hospital Halle (Saale), Halle, Germany.
Institute for Health and Nursing Science, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Halle, Germany; The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA; Nursing Research Unit, University Hospital Halle (Saale), Halle, Germany.
J Pain Symptom Manage. 2015 Jan;49(1):117-25. doi: 10.1016/j.jpainsymman.2014.04.007. Epub 2014 May 23.
Cancer patients frequently suffer from various symptoms often impairing functional status and quality of life. To enable timely supportive care, these symptoms must be assessed adequately with reliable tools.
This study aimed to validate the German version of the M. D. Anderson Symptom Inventory (MDASI).
This was a multicenter, cross-sectional, observational study. At five German university hospitals, 697 cancer patients aged from 18 to 80 years undergoing active anticancer treatment were recruited to participate in the study. For the validation, reliability (Cronbach's alpha), construct validity (factor analysis), known group validity (Eastern Cooperative Oncology Group Performance Status), and convergent divergent analyses were calculated.
Of the 980 patients who were eligible, 697 patients were included and agreed to participate in the study (71%). Reliability analysis showed good internal consistencies for the MDASI set of symptoms (Cronbach's alpha coefficient = 0.82; 95% CI = 0.78, 0.84) and for the set of interference items (Cronbach's alpha coefficient = 0.857; 95% CI = 0.484, 0.87). Factor analysis resulted in a one-factor solution (general symptoms; eigenvalue = 4.26) with a psychological (distress and sadness) and a gastrointestinal subscale (nausea and vomiting). Convergent and divergent analyses showed significant correlations between symptom burden and distress and global health-related quality of life (subscale of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 Version 3.0.).
The MDASI-German version is a valid tool for measuring patient-reported symptom severity and symptom interference in German cancer patients. It is easily applicable and can be used by German clinicians and researchers for screening and monitoring purposes and the comparison of international data.
癌症患者经常遭受各种症状的折磨，这些症状往往会损害其功能状态和生活质量。为了能够及时提供支持性护理，必须使用可靠的工具对这些症状进行充分评估。
本研究旨在验证MD安德森症状量表（MDASI）的德文版。
这是一项多中心、横断面观察性研究。在德国的五所大学医院，招募了697名年龄在18至80岁之间正在接受积极抗癌治疗的癌症患者参与该研究。为进行验证，计算了信度（克朗巴哈系数）、结构效度（因子分析）、已知组效度（东部肿瘤协作组体能状态）以及收敛和发散分析。
在980名符合条件的患者中，697名患者被纳入并同意参与研究（71%）。信度分析显示，MDASI症状组（克朗巴哈系数=0.82；95%可信区间=0.78,0.84）和干扰项目组（克朗巴哈系数=0.857；95%可信区间=0.484,0.87）具有良好内部一致性。因子分析得出单因素解（一般症状；特征值=4.26），包括心理亚量表（痛苦和悲伤）和胃肠道亚量表（恶心和呕吐）。收敛和发散分析表明，症状负担与痛苦以及全球健康相关生活质量（欧洲癌症研究与治疗组织生活质量问卷-C30第3.0版亚量表）之间存在显著相关性。
MDASI德文版是一种用于测量德国癌症患者报告的症状严重程度和症状干扰的有效工具。它易于应用，德国临床医生和研究人员可将其用于筛查、监测目的以及国际数据比较。
