Vasudevan Sanjay, Renuka J Valli, Sylvia D Sharon, Challa Radhika, Padmakanth M, Reddy Ajay
Professor and Head, Department of Periodontics, Army College of Dental Sciences, Secunderabad, Andhra Pradesh, India.
Senior Lecturer, Department of Periodontics, Army College of Dental Sciences, Jai Jawahar Nagar (CRPF Road), Chennapur, Secunderabad 500087, Andhra Pradesh, India, Phone: +91-9949997247, e-mail:
J Contemp Dent Pract. 2013 Nov 1;14(6):1165-8. doi: 10.5005/jp-journals-10024-1469.
To determine and correlate the effect of clomiphene citrate, Letrozole in women undergoing infertility treatment on the gingival inflammatory status.
The present study is a randomized controlled clinical trial which consisted of 26 women using CC for three menstrual cycles, 26 women using CC for more than three cycles, 26 women using Letrozole. All subjects were clinically examined for plaque levels (Plaque Index), gingival inflammation, bleeding on probing (Gingival Index, Sulcus Bleeding Index). Scaling was done to all patients and all periodontal parameters were reassessed 1 month after scaling. The results were compared with a control group of 26 women matched for age, educational status and professional level, and oral habits and who had never used ovulation drugs.
Baseline scores of all the test groups showed higher amount of plaque levels and inflammation compared to control. (p < 0.05). After scaling a significant reduction in inflammation was observed in all the test groups along with the control group (p < 0.0001), but women using the drugs showed persistence of inflammation compared to control (p < 0.01).
It can be concluded from the present study that the presence of elevated levels of hormones due to the effect of ovulation induction drugs may be the reason for the gingival inflammation in test groups.
确定枸橼酸氯米芬、来曲唑对接受不孕症治疗的女性牙龈炎症状态的影响并进行相关性分析。
本研究为一项随机对照临床试验，包括26名使用枸橼酸氯米芬三个月经周期的女性、26名使用枸橼酸氯米芬超过三个周期的女性、26名使用来曲唑的女性。对所有受试者进行临床检查，评估菌斑水平（菌斑指数）、牙龈炎症、探诊出血情况（牙龈指数、龈沟出血指数）。对所有患者进行龈上洁治，洁治1个月后重新评估所有牙周参数。将结果与一个由26名年龄、教育程度、职业水平、口腔习惯匹配且从未使用过促排卵药物的女性组成的对照组进行比较。
与对照组相比，所有试验组的基线评分显示菌斑水平和炎症程度更高（p < 0.05）。洁治后，所有试验组和对照组的炎症均显著减轻（p < 0.0001），但与对照组相比，使用药物的女性炎症持续存在（p < 0.01）。
从本研究可以得出结论，促排卵药物作用导致激素水平升高可能是试验组牙龈炎症的原因。
