Gonugunta Vijay K, Miao Lu, Sareddy Gangadhara R, Ravindranathan Preethi, Vadlamudi Ratna, Raj Ganesh V
Department of UrologyUT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USADepartment of Obstetrics and GynecologyUT Health Science Center, San Antonio, Texas, USA.
Department of UrologyUT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USADepartment of Obstetrics and GynecologyUT Health Science Center, San Antonio, Texas, USA
Endocr Relat Cancer. 2014 Aug;21(4):T79-86. doi: 10.1530/ERC-13-0502. Epub 2014 May 23.
Proline, glutamic acid- and leucine-rich protein 1 (PELP1) is a multi-domain scaffold protein that serves as a platform for various protein-protein interactions between steroid receptors (SRs) and signaling factors and cell cycle, transcriptional, cytoskeletal, and epigenetic remodelers. PELP1 is known to be a coregulator of transcription and participates in the nuclear and extranuclear functions of SRs, ribosome biogenesis, and cell cycle progression. The expression and localization of PELP1 are dysregulated in hormonal cancers including breast and prostate cancers. This review focuses on the interactive functions and therapeutic and prognostic significance of PELP1 in breast and prostate cancers.
富含脯氨酸、谷氨酸和亮氨酸的蛋白1（PELP1）是一种多结构域支架蛋白，作为类固醇受体（SRs）与信号因子以及细胞周期、转录、细胞骨架和表观遗传重塑因子之间各种蛋白质-蛋白质相互作用的平台。已知PELP1是转录共调节因子，参与SRs的核内和核外功能、核糖体生物发生以及细胞周期进程。PELP1的表达和定位在包括乳腺癌和前列腺癌在内的激素依赖性癌症中失调。本综述重点关注PELP1在乳腺癌和前列腺癌中的相互作用功能以及治疗和预后意义。
