Tianjin University of Traditional Chinese Medicine, 312 Anshan Western Road, Nankai District, Tianjin, P.R. China. ; Ethiopian Health and Nutrition Research Institute, Arbegnoch Road, Addis Ababa, Ethiopia.
Tianjin University of Traditional Chinese Medicine, 312 Anshan Western Road, Nankai District, Tianjin, P.R. China.
J Tradit Complement Med. 2014 Apr;4(2):93-8. doi: 10.4103/2225-4110.126635.
Inflammation is a normal immune response; but if the body's regulation of inflammation is dysfunctional, then it will have an adverse effect on the body. Although use of modern drugs for inflammation has a relieving effect, it is still unsatisfactory. Moreover, the emergence of drug-resistant strains and even new kinds of microorganisms is causing significant morbidity and mortality. Recently, more attention has been focused on herbal medicine to treat various diseases because of the ability of the herbs to affect multiple target signaling pathways and their multiple mechanisms of action. Thus, a large number of studies have reported on the anti-inflammatory and antimicrobial effects of the traditional Chinese herbs. Literature survey was performed by conducting systematic electronic search in PubMed, Science Direct, Google Scholar, and in books. This review has listed 11 heat-clearing Chinese herbs (HCCHs) including Scutellaria baicalensis ( Huáng Qín), Coptis chinensis ( Huáng Lián), Flos Lonicerae ( Jīn Yín Hūa), Forsythia suspensa ( Lián Qiào), Isatidis Folium ( Dà Qīn Yè), Radix Isatidis ( Bǎn Lán Gēn), Viola yedoensis ( Zǐ Huā Dì Dīn), Pulsatilla Radix ( Bái Tóu Wēn), Andrographis paniculata ( Chuān Xīn Lián), Houttuynia cordata ( Yú Xīng Cǎo), and Patrinia Herba ( Bài Jiàn Cǎo), which have anti-inflammatory and antimicrobial effects, and has described their effects through different mechanisms of action and multiple targets. Their ability to affect multiple target signaling pathways and their potential mechanisms of action contributing to their anti-inflammatory and antimicrobial activity may be related to their action of removing heat and counteracting toxicity. Further studies are needed on the collection of HCCHs to know the detailed mechanism of action of herbs in this group for the assessment of effective drug.
炎症是一种正常的免疫反应；但如果身体对炎症的调节功能失调，就会对身体产生不良影响。虽然现代药物对炎症有缓解作用，但仍不理想。此外，耐药菌株的出现，甚至新的微生物种类的出现，正在导致发病率和死亡率的显著上升。最近，由于草药能够影响多个靶标信号通路及其多种作用机制，人们越来越关注草药治疗各种疾病的能力。因此，大量研究报告了传统中药的抗炎和抗菌作用。通过在 PubMed、Science Direct、Google Scholar 和书籍中进行系统的电子搜索，进行了文献调查。本综述列出了 11 种清热中药（HCCHs），包括黄芩（Huang Qin）、黄连（Huang Lian）、金银花（Jin Yin Hua）、连翘（Lian Qiao）、淡竹叶（Da Qin Ye）、板蓝根（Ban Lan Gen）、菘蓝（Zi Hua Di Yin）、白头翁（Bai Tou Wen）、穿心莲（Chuan Xin Lian）、鱼腥草（Yu Xing Cao）和败酱草（Bai Jian Cao），它们具有抗炎和抗菌作用，并通过不同的作用机制和多个靶点描述了它们的作用。它们影响多个靶标信号通路的能力及其抗炎和抗菌活性的潜在作用机制可能与它们的清热解毒作用有关。需要进一步研究 HCCHs 的采集，以了解该组草药的详细作用机制，从而评估有效药物。
