Motswaledi M H, Khammissa R A G, Jadwat Y, Lemmer J, Feller L
Department of Dermatology, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa.
Aust Dent J. 2014 Sep;59(3):389-94. doi: 10.1111/adj.12196. Epub 2014 Jul 30.
Sarcoidosis is a chronic multi-system immuno-inflammatory disorder characterized by non-caseating granulomatous infiltration of affected tissues that may result in fibrosis and organ dysfunction. It generally affects genetically predisposed young adults who develop a local dysregulated cell-mediated immune response towards an undefined 'sarcoidal antigen'. From recent data, it has become evident that Propionibacterium acnes and Mycobacterium tuberculosis are the probable antigenic agents which initiate sarcoidosis. Oral sarcoidosis is rare with only about 70 cases having been reported in the literature. The purpose of this report is to present a case of oral and cutaneous sarcoidosis in a black female that was probably triggered by mycobacteria.
结节病是一种慢性多系统免疫炎症性疾病，其特征是受累组织出现非干酪样肉芽肿浸润，这可能导致纤维化和器官功能障碍。它通常影响具有遗传易感性的年轻成年人，这些人会针对一种不明的“结节病抗原”产生局部失调的细胞介导免疫反应。从最近的数据来看，痤疮丙酸杆菌和结核分枝杆菌显然是引发结节病的可能抗原剂。口腔结节病很罕见，文献中仅报道了约70例。本报告的目的是介绍一例黑人女性的口腔和皮肤结节病病例，该病例可能由分枝杆菌引发。
