Arana J, Tovar J A, Tapia I
Cir Pediatr. 1989 Jul;2(3):123-8.
We have investigated manometrically wether esophageal motor response (in terms of frequency and mean pressure of propulsive and non-propulsive waves) to the instillation of saline and 0.1 N HCl into the lumen was different in normal (n = 18) and refluxing (n = 66) patients. Instillation of saline induced bursts of non-propulsive waves both in normal and refluxing patients. Additionally, it induced in the latter an increase in propulsive waves. Instillation of acid did not induce in normal subjects changes different from those generated by saline but stimulated considerably the refluxing esophagus which responded with an increased number of more powerful waves. This results suggest that refluxing esophagus is hypocontractile as compared with the healthy one and that it is awaken by acid as if it tried to improve its motor efficiency.
我们通过测压法研究了正常患者（n = 18）和反流患者（n = 66）食管对向管腔内注入生理盐水和0.1N盐酸的运动反应（根据推进波和非推进波的频率及平均压力）是否存在差异。在正常患者和反流患者中，注入生理盐水均诱发了非推进波的爆发。此外，在反流患者中，它还诱发了推进波的增加。在正常受试者中，注入酸并未诱发与注入生理盐水所产生的反应不同的变化，但却显著刺激了反流性食管，反流性食管会以更多更强有力的波作出反应。这些结果表明，与健康食管相比，反流性食管收缩功能减退，并且它会被酸唤醒，就好像它试图提高其运动效率一样。
