School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 China.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):4236-43. doi: 10.1016/j.msec.2013.06.022. Epub 2013 Jun 26.
Acid-catalyzed mesoporous bioactive glass microspheres (MBGMs-A) and acid-alkali co-catalyzed mesoporous bioactive glass microspheres (MBGMs-B) were successfully synthesized via combination of sol-gel and water-in-oil (W/O) micro-emulsion methods. The structural, morphological and textural properties of mesoporous bioactive glass microspheres (MBGMs) were characterized by various techniques. Results show that both MBGMs-A and MBGMs-B exhibit regularly spherical shape but with different internal porous structures, i.e., a dense microstructure for MBGMs-A and internally porous structure for MBGMs-B. (29)Si NMR data reveal that MGBMs have low polymerization degree of silica network. The in vitro bioactivity tests indicate that the apatite formation rate of MBGMs-B was faster than that of MBGMs-A after soaking in simulated body fluid (SBF) solution. Furthermore, the two kinds of MBGMs have similar storage capacity of alendronate (AL), and the release behaviors of AL could be controlled due to their unique porous structure. In conclusion, the microspheres are shown to be promising candidates as bone-related drug carriers and filling materials of composite scaffold for bone repair.
酸催化介孔生物活性玻璃微球（MBGMs-A）和酸-碱共催化介孔生物活性玻璃微球（MBGMs-B）通过溶胶-凝胶法和油包水（W/O）微乳液法相结合成功合成。采用多种技术对介孔生物活性玻璃微球（MBGMs）的结构、形态和结构特性进行了表征。结果表明，MBGMs-A 和 MBGMs-B 均呈现出规则的球形，但具有不同的内部多孔结构，即 MBGMs-A 为致密的微观结构，MBGMs-B 为内部多孔结构。（29）Si NMR 数据表明，MGBMs 的硅网络聚合度较低。体外生物活性测试表明，在模拟体液（SBF）溶液浸泡后，MBGMs-B 的磷灰石形成速率快于 MBGMs-A。此外，两种 MBGMs 对阿仑膦酸钠（AL）的储存能力相似，由于其独特的多孔结构，可以控制 AL 的释放行为。总之，这些微球有望成为骨相关药物载体和骨修复复合支架填充材料的候选材料。
