Silveira F T, Lainson R, Shaw J J, Garcez L M, Souza A A, Braga R R, Ishikawa E A
Rev Soc Bras Med Trop. 1989 Jul-Sep;22(3):125-30. doi: 10.1590/s0037-86821989000300003.
The susceptibility of the monkey Cebus apella (Cebidae) to experimental infection by Leishmania (Viannia) lainsoni has been investigated. For this purpose, five young monkeys, 2 males and 3 females, were intradermally, inoculated, in eight different places along the dorsal surface of the tail with 3 x 10(6) promastigotes of the parasite (MHOM/BR/81/M6426, Benevides, Pará), from stationary phase culture in Difco B45 medium. After inoculations, infection in the monkeys was indicated by the presence of amastigotes in the skin lesions produced in these animals at the points of inoculation, confirming the susceptibility of the monkey Cebus apella to experimental infection by Leishmania lainsoni, with an infection period of four months. This represents a suitable period for testing antileishmanial drugs or studying the pathogenesis of the disease caused by this parasite.
已对僧帽猴（卷尾猴科）感染赖氏利什曼原虫（维氏亚属）的易感性进行了研究。为此，选用了5只幼猴，2只雄性和3只雌性，在其尾巴背面沿尾长方向的8个不同部位皮内接种3×10⁶个处于稳定期培养的寄生虫（MHOM/BR/81/M6426，贝内维德斯，帕拉州）前鞭毛体，该寄生虫培养于Difco B45培养基中。接种后，在接种部位产生的皮肤病变中发现无鞭毛体，表明这些猴子已被感染，从而证实了僧帽猴对赖氏利什曼原虫实验性感染的易感性，感染期为4个月。这是测试抗利什曼药物或研究该寄生虫所致疾病发病机制的适宜时期。
