Tong Jian-hua, Li Zhi, Shi Jing, Li He-ming, Wang Yan, Fu Ling-yu, Liu Yun-peng
Department of Medical Oncology, The First Hospital, China Medical University, Shenyang, China.
PLoS One. 2014 May 27;9(5):e97498. doi: 10.1371/journal.pone.0097498. eCollection 2014.
The relationship between passive smoking exposure (PSE) and breast cancer risk is of major interest.
To evaluate the relationship between PSE from partners and breast cancer risk stratified by hormone-receptor (HR) status in Chinese urban women population.
Hospital-based matched case control study.
Chinese urban breast cancer patients without current or previous active smoking history in China Medical University 1st Hospital, Liaoning Province, China between Jan 2009 and Nov 2009.
Each breast cancer patient was matched 1∶1 with healthy controls by gender and age (±2 years) from the same hospital.
The authors used unconditional logistic regression analyses to estimate odds ratio for women with PSE from partners and breast cancer risk.
312 pairs were included in the study. Women who endured PSE had significantly increased risk of breast cancer (adjusted OR: 1.46; 95% CI: 1.05-2.03; P = 0.027), comparing with unexposed women. Women who exposed to >5 cigarettes/day also had significant increased risk (adjusted OR: 1.99; 95% CI: 1.28-3.10; P = 0.002), as were women exposed to passive smoke for 16-25 years (adjusted OR: 1.87 95% CI: 1.22-2.86; P = 0.004), and those exposed to > 4 pack-years (adjusted OR: 1.71 95% CI: 1.17-2.50; P = 0.004). Similar trends were significant for estrogen receptor (ER)/progesterone receptor (PR) double positive subgroup(adjusted OR: 1.71; 2.20; 1.99; 1.92, respectively), but not for ER+/PR-, ER-/PR+, or ER-/PR- subgroups.
limitations of the hospital-based retrospective study, lack of information on entire lifetime PSE and low statistical power.
Our findings provide further evidence that PSE from partners contributes to increased risk of breast cancer, especially for ER/PR double positive breast cancer, in Chinese urban women.
被动吸烟暴露（PSE）与乳腺癌风险之间的关系备受关注。
评估中国城市女性人群中伴侣的PSE与按激素受体（HR）状态分层的乳腺癌风险之间的关系。
基于医院的配对病例对照研究。
2009年1月至2009年11月期间，中国辽宁省中国医科大学附属第一医院无当前或既往主动吸烟史的中国城市乳腺癌患者。
每位乳腺癌患者与来自同一家医院的健康对照按性别和年龄（±2岁）进行1∶1配对。
作者使用无条件逻辑回归分析来估计伴侣有PSE的女性患乳腺癌风险的比值比。
该研究纳入了312对。与未暴露女性相比，遭受PSE的女性患乳腺癌的风险显著增加（调整后的比值比：1.46；95%可信区间：1.05 - 2.03；P = 0.027）。每天暴露于超过5支香烟的女性风险也显著增加（调整后的比值比：1.99；95%可信区间：1.28 - 3.10；P = 0.002），暴露于被动吸烟16 - 25年的女性（调整后的比值比：1.87，95%可信区间：1.22 - 2.86；P = 0.004），以及暴露超过4包年的女性（调整后的比值比：1.71，95%可信区间：1.17 - 2.50；P = 0.004）。雌激素受体（ER）/孕激素受体（PR）双阳性亚组也有类似的显著趋势（调整后的比值比分别为：1.71；2.20；1.99；1.92），但ER+/PR-、ER-/PR+或ER-/PR-亚组则没有。
基于医院的回顾性研究的局限性，缺乏关于终生PSE的信息以及统计效力较低。
我们的数据进一步证明，伴侣的PSE会增加中国城市女性患乳腺癌的风险，尤其是对于ER/PR双阳性乳腺癌。
