Chou I-Ching, Lin Che-Chen, Sung Fung-Chang, Kao Chia-Hung
Department of Paediatrics, China Medical University Hospital, China Medical University, Taichung, Taiwan; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
Dev Med Child Neurol. 2014 Nov;56(11):1111-6. doi: 10.1111/dmcn.12501. Epub 2014 May 28.
Attention-deficit-hyperactivity disorder (ADHD) is a disorder that is associated with accidental injuries. The aim of this study was to evaluate the relationship between ADHD and bone fracture in children.
The study cohort comprised 3640 children (2874 males, 766 females; mean age 8y 5mo, SD 3y) with ADHD (International Classification of Diseases, Ninth Revision) who were matched to children without ADHD at a ratio of 1:4 (n=14 560; 11 496 males, 3064 females; mean age 8y 5mo, SD 3y). A Cox proportional hazard regression analysis was conducted to estimate how ADHD affected the risk of bone fracture.
The incidence of fracture among the ADHD cohort was 197.67 per 10,000 person-years, and was 1.3-fold greater than in the comparison cohort (147.54 per 10,000 person-years). The risk in children with ADHD was higher than that in children without ADHD (p value for log-rank test < 0.001). After adjusting for potential confounding factors, the ADHD cohort was 1.32 times more likely to have bone fracture accidents than the comparison cohort (hazard ratio, 1.32; 95% confidence interval 1.17-1.49).
Children with ADHD have a higher risk of experiencing bone fracture accidents than do children without ADHD.
注意力缺陷多动障碍（ADHD）是一种与意外伤害相关的疾病。本研究的目的是评估儿童ADHD与骨折之间的关系。
研究队列包括3640名患有ADHD（国际疾病分类第九版）的儿童（2874名男性，766名女性；平均年龄8岁5个月，标准差3岁），这些儿童与未患ADHD的儿童按1:4的比例匹配（n = 14560；11496名男性，3064名女性；平均年龄8岁5个月，标准差3岁）。进行Cox比例风险回归分析以估计ADHD如何影响骨折风险。
ADHD队列中的骨折发生率为每10000人年197.67例，比对照组（每10000人年147.54例）高1.3倍。ADHD儿童的风险高于未患ADHD的儿童（对数秩检验p值<0.001）。在调整潜在混杂因素后，ADHD队列发生骨折事故的可能性比对照组高1.32倍（风险比，1.32；95%置信区间1.17 - 1.49）。
与未患ADHD的儿童相比，患有ADHD的儿童发生骨折事故的风险更高。
