Rivera Cisneros A E, Díaz Cisneros F J, Guerrero González H, García González M R, Negrete García C, Mendiola Anda C
Instituto de Investigación sobre Trabajo Universidad de Guanajuato.
Arch Inst Cardiol Mex. 1989 Jan-Feb;59(1):29-34.
The purpose of this study was to evaluate the effects of body postural changes (supine-upright), upon the serum concentration of cholesterol (CT), triglycerides (TG), high density lipoproteins (HDL), low density (LDL) and very low density lipoproteins (VLDL) and hemoglobin, hematocrit, and plasma proteins (to calculate delta% change in plasma y volume). Nine healthy men participated as subjects. Their age ranged from 32 +/- 3 years old, and 16 +/- 4% body fat (X +/- SD). After 10-12 hours post absorptive and appropriate rest, they performed a standard orthostatic maneuver: subjects remained supine for 30 minutes, then assumed the standing position (unsupported and with minimal movement) for additional 30 minutes. Blood samples were obtained after 30 minutes supine and at 10, 20 and 30 minutes of standing. At 10 minutes of orthostatism, CT, TG, HDL and VLDL had a significant increase as compared to supine values; these changes were associated with a reduction of 8.9% on plasma volume (PV) (p less than 0.05). After 30 minutes of orthostatism CT, TG, HDL and VLDL showed increments of 8.5%, 33.3%, 20.1% and 32% respectively, in relation to the supine values (p less than 0.05). Changes on serum lipids were associated with PV reductions until 20 minutes of orthostatism. However, there was not a significant association between these variables at 30 minutes of standing. These data indicated that the body position and the time in which blood samples are obtained significantly influence lipid and lipoprotein serum level. Therefore, in any study related to lipids, such variables should be considered and properly controlled.
本研究的目的是评估身体姿势变化（仰卧位-直立位）对血清胆固醇（CT）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）浓度以及血红蛋白、血细胞比容和血浆蛋白的影响（以计算血浆容量的变化百分比）。九名健康男性作为受试者参与研究。他们的年龄在32±3岁之间，体脂率为16±4%（X±SD）。在吸收后10 - 12小时并经过适当休息后，他们进行了标准的直立位动作：受试者仰卧30分钟，然后保持站立姿势（无支撑且动作最小）30分钟。在仰卧30分钟后以及站立10、20和30分钟时采集血样。在直立位10分钟时，与仰卧位值相比，CT、TG、HDL和VLDL显著升高；这些变化与血浆容量（PV）减少8.9%相关（p < 0.05）。直立位30分钟后，与仰卧位值相比，CT、TG、HDL和VLDL分别升高了8.5%、33.3%、20.1%和32%（p < 0.05）。直到直立位20分钟，血脂变化与PV减少相关。然而，在站立30分钟时，这些变量之间没有显著关联。这些数据表明，身体姿势以及采集血样的时间显著影响血清脂质和脂蛋白水平。因此，在任何与脂质相关的研究中，都应考虑并适当控制这些变量。
