Centre for Physical Activity and Nutrition ResearchSchool of Exercise and Nutrition Sciences, Deakin University, Burwood, Melbourne, Victoria 3125, AustraliaLivestock and Farming SystemsSouth Australian Research and Development Institute, University of Adelaide, Roseworthy, Adelaide, South Australia 5371, Australia.
Centre for Physical Activity and Nutrition ResearchSchool of Exercise and Nutrition Sciences, Deakin University, Burwood, Melbourne, Victoria 3125, AustraliaLivestock and Farming SystemsSouth Australian Research and Development Institute, University of Adelaide, Roseworthy, Adelaide, South Australia 5371, Australia
Endocr Connect. 2014 Sep;3(3):110-9. doi: 10.1530/EC-14-0042.
We tested the hypothesis that overweight/obese men aged 50-70 years will have a greater salivary cortisol, salivary alpha amylase and heart rate (HR) responses to psychological stress compared with age matched lean men. Lean (BMI=20-25 kg/m(2); n=19) and overweight/obese (BMI=27-35 kg/m(2); n=17) men (50-70 years) were subjected to a well-characterised psychological stress (Trier Social Stress Test, TSST) at 1500 h. Concentrations of cortisol and alpha amylase were measured in saliva samples collected every 7-15 min from 1400 to 1700 h. HR was recorded using electrocardiogram. Body weight, BMI, percentage body fat, resting systolic and diastolic blood pressure and mean arterial pressure were significantly higher (P<0.05) in overweight/obese men compared with lean men. Both groups responded to the TSST with a substantial elevation in salivary cortisol (372%), salivary alpha amylase (123%) and HR (22%). These responses did not differ significantly between the groups (time×treatment interaction for salivary cortisol, salivary alpha amylase and HR; P=0.187, P=0.288, P=0.550, respectively). There were no significant differences between the groups for pretreatment values, peak height, difference between pretreatment values and peak height (reactivity) or area under the curve for salivary cortisol, salivary alpha amylase or HR (P>0.05 for all). The results showed that, for men with a moderate level of overweight/obesity who were otherwise healthy, the response of salivary cortisol, salivary alpha amylase and HR to acute psychological stress was not impaired.
我们检验了这样一个假设，即年龄在 50-70 岁之间的超重/肥胖男性在面对心理压力时，唾液皮质醇、唾液 α-淀粉酶和心率（HR）的反应会比同龄的正常体重男性更大。将 19 名体重正常（BMI=20-25kg/m2）和 17 名超重/肥胖（BMI=27-35kg/m2）男性（50-70 岁）在 1500 时进行了一项经过充分特征描述的心理压力测试（Trier 社会应激测试，TSST）。从 1400 到 1700，每隔 7-15 分钟采集唾液样本，测量皮质醇和 α-淀粉酶的浓度。使用心电图记录 HR。超重/肥胖男性的体重、BMI、体脂百分比、静息收缩压和舒张压以及平均动脉压明显高于体重正常男性（P<0.05）。两组男性对 TSST 的反应都是唾液皮质醇（372%）、唾液 α-淀粉酶（123%）和 HR（22%）显著升高。两组之间这些反应没有显著差异（唾液皮质醇、唾液 α-淀粉酶和 HR 的时间×治疗相互作用；P=0.187、P=0.288、P=0.550）。两组之间的预处理值、峰值高度、预处理值与峰值高度之间的差异（反应性）或唾液皮质醇、唾液 α-淀粉酶或 HR 的曲线下面积均无显著差异（P>0.05）。结果表明，对于那些健康状况中等程度超重/肥胖的男性，急性心理压力对唾液皮质醇、唾液 α-淀粉酶和 HR 的反应并没有受损。
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