Yang S J, Cho J G, Park J C, Kang J C
Korean J Intern Med. 1989 Jul;4(2):148-54. doi: 10.3904/kjim.1989.4.2.148.
The right pulmonary artery (RPA) dimensions of 85 asymptomatic mild or moderate hypertension (HT) patients, divided into 6 subgroups according to the left ventricular (LV) mass index (125g/m2 BSA) left atrial (LA) dimension index (2.2cm/m2 BSA), and 40 normal subjects were studied utilizing suprasternal M-mode echocardiography in order to examine the consistency of the elevated PA pressure in essential HT and to understand its pathogenesis. The RPA dimension at late diastole, at the end of the right ventricular isovolumic contraction, and at systole in the subgroup of HT without LV hypertrophy and LA enlargement was significantly increased compared with those of the normal group (18.4 +/- 2.8 vs 16.2 +/- 2.3mm, 19.6 +/- 3.0 vs 17.2 +/- 1.3mm, 22.5 +/- 2.5 vs 20.8 +/- 1.9mm, p less than 0.05, respectively) and varied in close correlation with systolic and diastolic BP and the dimension of the aorta. The dimensions in the other 5 subgroups were the same and were not further affected by the LV mass and LA dimension. The above results suggest that elevated systemic BP per se is associated with the dilation of the RPA supposedly caused by increased PA resistance, besides the backward effect of the increased LV and/or LA pressure which may affect the increase of PA pressure.
对85例无症状轻度或中度高血压(HT)患者的右肺动脉(RPA)尺寸进行了研究,这些患者根据左心室(LV)质量指数(125g/m²体表面积)、左心房(LA)尺寸指数(2.2cm/m²体表面积)分为6个亚组,另外还有40名正常受试者,采用胸骨上M型超声心动图检查,以检验原发性高血压中肺动脉压力升高的一致性,并了解其发病机制。在无LV肥厚和LA扩大的HT亚组中,舒张末期、右心室等容收缩末期和收缩期的RPA尺寸与正常组相比显著增加(分别为18.4±2.8 vs 16.2±2.3mm、19.6±3.0 vs 17.2±1.3mm、22.5±2.5 vs 20.8±1.9mm,p均<0.05),且与收缩压和舒张压以及主动脉尺寸密切相关。其他5个亚组的尺寸相同,且未进一步受LV质量和LA尺寸的影响。上述结果表明,除了LV和/或LA压力升高的逆向作用可能影响肺动脉压力增加外,全身血压升高本身与RPA扩张有关,推测这是由肺动脉阻力增加所致。