Affiliations of authors: Masonic Cancer Center (RIV, HHN, DL), Department of Dermatology (RLA), and Division of Epidemiology and Community Health (HHN, DL), University of Minnesota, Minneapolis, MN; Department of Internal Medicine and University of New Mexico Cancer Center, Albuquerque, NM (MB); Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque, NM (MB); Dermatoepidemiology Unit, VA Medical Center, Providence, RI (MAW); Department of Dermatology, Rhode Island Hospital, Providence, RI (MAW); Departments of Dermatology and Community Health, Brown University, Providence, RI (MAW).
J Natl Cancer Inst. 2014 May 28;106(6):dju112. doi: 10.1093/jnci/dju112. Print 2014 Jun.
Indoor tanning is carcinogenic to humans. Individuals report that they tan indoors before planning to be in the sun to prevent sunburns, but whether skin cancer is subsequently reduced is unknown. Using a population-based case-control study, we calculated the association between melanoma and indoor tanning after excluding exposed participants reporting indoor tanning-related burns, stratified by their number of lifetime sunburns (0, 1-2, 3-5, >5). Confounding was addressed using propensity score analysis methods. All statistical tests were two-sided. We observed increased risk of melanoma across all sunburn categories for participants who had tanned indoors without burning compared with those who never tanned indoors, including those who reported zero lifetime sunburns (odds ratio = 3.87; 95% confidence interval = 1.68 to 8.91; P = .002). These data provide evidence that indoor tanning is a risk factor for melanoma even among persons who reported never experiencing burns from indoor tanning or outdoor sun exposure.
室内晒黑对人类具有致癌性。人们报告说，他们在计划晒太阳之前会在室内晒黑以防止晒伤，但随后是否会减少皮肤癌尚不清楚。使用基于人群的病例对照研究，我们在排除了报告与室内晒黑相关灼伤的暴露参与者后，根据他们一生中晒伤的次数（0、1-2、3-5、>5），计算了黑色素瘤与室内晒黑之间的关联。使用倾向评分分析方法解决混杂因素。所有统计检验均为双侧检验。我们观察到，与从未在室内晒黑的参与者相比，在所有晒伤类别中，室内晒黑且未灼伤的参与者患黑色素瘤的风险均增加，包括报告一生中从未晒伤过的参与者（比值比=3.87；95%置信区间=1.68 至 8.91；P=.002）。这些数据表明，即使是那些从未经历过室内晒黑或户外阳光暴露灼伤的人，室内晒黑也是黑色素瘤的一个风险因素。
