洛尼农村人口中氨氯地平所致牙龈增生的发病率。
Incidence of amlodipine-induced gingival overgrowth in the rural population of Loni.
作者信息
Tejnani Avneesh, Mani Ameet, Sodhi Neha Kaur, Mehta Alok, Gourkhede Sonal, Thorat Vinayak, Marawar Pramod
机构信息
GSBS Medical Trust, Loni, Maharashtra, India.
Department of Periodontology, Rural Dental College, Loni, India.
出版信息
J Indian Soc Periodontol. 2014 Mar;18(2):226-8. doi: 10.4103/0972-124X.131332.
AIMS
Since the incidence of gingival overgrowth induced by amlodipine remains poorly defined, this study was carried out with an aim to determine the incidence.
MATERIALS AND METHODS
Dental patients who received amlodipine (N = 115), for more than 3 months were studied to determine the drug-induced gingival overgrowth. Clinical diagnosis of drug-induced overgrowth was verified by disappearance or decreased severity of gingival overgrowth after withdrawal of the causative drug.
RESULTS
The prevalence rate of amlodipine-induced gingival hyperplasia among experimental patients was 3.4%, while it was not observed among the control subjects. Oral examination revealed gingival overgrowth as a lobular or nodular enlargement on interdental papilla located in the anterior interproximal regions.
CONCLUSIONS
In this study, there was a significant relationship between gingival inflammation resulting from dental plaque and drug dosage, and hyperplasia.
目的
由于氨氯地平所致牙龈增生的发生率仍不明确，开展本研究以确定其发生率。
材料与方法
对接受氨氯地平治疗超过3个月的牙科患者（N = 115）进行研究，以确定药物性牙龈增生情况。通过停用致病药物后牙龈增生消失或严重程度降低来证实药物性增生的临床诊断。
结果
试验组患者中氨氯地平所致牙龈增生的患病率为3.4%，而对照组未观察到该情况。口腔检查发现牙龈增生表现为位于前牙邻面区域的牙间乳头呈小叶状或结节状肿大。
结论
在本研究中，牙菌斑引起的牙龈炎症与药物剂量和增生之间存在显著关系。
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