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川芎嗪对长时间直立姿势诱导的大鼠腰椎间盘退变的保护作用。

Protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture.

机构信息

Institute of Spine, Shanghai University of Traditional Chinese Medicine, 725 Wan-Ping South Road, Shanghai 200032, China ; Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

出版信息

Evid Based Complement Alternat Med. 2014;2014:508461. doi: 10.1155/2014/508461. Epub 2014 Apr 29.

DOI:10.1155/2014/508461
PMID:24872832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4020374/
Abstract

Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of ligustrazine on disc degeneration, we applied a rat model. The intervertebral disc degeneration of the rats was induced by prolonged upright posture. We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1 β , cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression. In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease.

摘要

大多数慢性下腰痛是腰椎间盘退变的结果。川芎嗪是川芎中的一种生物碱，据报道具有止痛、抑制炎症和治疗骨关节炎的作用，对软骨和软骨细胞具有保护作用。因此，我们想知道川芎嗪是否能减轻椎间盘退变。为了确定川芎嗪对椎间盘退变的影响，我们建立了大鼠模型。通过长时间的直立姿势诱导大鼠椎间盘退变。我们发现，川芎嗪预处理 1 个月可恢复退行性椎间盘的结构扭曲；抑制型 X 胶原、基质金属蛋白酶（MMP）-13 和 MMP3 的表达；上调型 II 胶原；降低 IL-1β、环氧化酶（COX）-2 和诱导型一氧化氮合酶（iNOS）的表达。总之，川芎嗪是治疗腰椎间盘退行性疾病有前途的药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/9d1d6e19f260/ECAM2014-508461.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/8ce6a023c746/ECAM2014-508461.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/991c42e626b0/ECAM2014-508461.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/b16f38941cc4/ECAM2014-508461.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/4bdf0fd54861/ECAM2014-508461.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/d2cdb3196399/ECAM2014-508461.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/9d1d6e19f260/ECAM2014-508461.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/8ce6a023c746/ECAM2014-508461.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/991c42e626b0/ECAM2014-508461.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/b16f38941cc4/ECAM2014-508461.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/4bdf0fd54861/ECAM2014-508461.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/d2cdb3196399/ECAM2014-508461.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ac/4020374/9d1d6e19f260/ECAM2014-508461.006.jpg

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