Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
Pharmaceutical Industries Research Division, Pharmacognosy Department, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, P.O. 12622, Giza, Egypt.
J Nat Med. 2020 Mar;74(2):409-414. doi: 10.1007/s11418-019-01377-6. Epub 2019 Dec 13.
Three new polyacetylenic alcohols, siphonellanols A-C (1-3), together with two known polyacetylenic alcohols (4-5), were isolated from the CHCl-soluble fraction of the methanolic extract of the marine sponge Siphonochalina siphonella, collected in Egypt. The structures of 1-3 were determined by spectroscopic analyses of their 1D-, 2D-NMR, and MS spectra and by comparisons with reported data. The cytotoxicity assay revealed that 1-3 exhibited moderate cytotoxic activities against a human cervical cancer cell line (HeLa), a human breast cancer cell line (MCF-7), and a human lung cancer cell line (A549) with IC values ranging from 25.9 to 69.2 μM.
从埃及采集的海洋海绵 Siphonochalina siphonella 的甲醇提取物的 CHCl 可溶部分中分离得到三种新的聚乙炔醇，即 siphonellanols A-C（1-3），以及两种已知的聚乙炔醇（4-5）。通过对它们的 1D-NMR、2D-NMR 和 MS 谱的光谱分析以及与报道的数据进行比较，确定了 1-3 的结构。细胞毒性测定表明，1-3 对人宫颈癌细胞系（HeLa）、人乳腺癌细胞系（MCF-7）和人肺癌细胞系（A549）具有中等的细胞毒性活性，IC 值范围为 25.9 至 69.2 μM。
