Department of Orthopaedic Surgery, New York University Medical Center, New York, NY 10003, USA ; Department of Orthopaedic Surgery, Shandong University, Jinan, Shandong 250012, China.
Department of Orthopaedic Surgery, New York University Medical Center, New York, NY 10003, USA.
Mediators Inflamm. 2014;2014:649718. doi: 10.1155/2014/649718. Epub 2014 Apr 28.
ADAMTS-12 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which were known to play important roles in various biological and pathological processes, such as development, angiogenesis, inflammation, cancer, arthritis, and atherosclerosis. In this review, we briefly summarize the structural organization of ADAMTS-12; concentrate on the emerging role of ADAMTS-12 in several pathophysiological conditions, including intervertebral disc degeneration, tumorigenesis and angioinhibitory effects, pediatric stroke, gonad differentiation, trophoblast invasion, and genetic linkage to schizophrenia and asthma, with special focus on its role in arthritis and inflammation; and end with the perspective research of ADAMTS-12 and its potential as a promising diagnostic and therapeutic target in various kinds of diseases and conditions.
ADAMTS-12 是解整合素金属蛋白酶与凝血酶样金属蛋白酶（ADAMTS）家族蛋白酶的成员，已知其在各种生物学和病理过程中发挥重要作用，如发育、血管生成、炎症、癌症、关节炎和动脉粥样硬化。在这篇综述中，我们简要总结了 ADAMTS-12 的结构组织；重点介绍了 ADAMTS-12 在几种病理生理条件下的新作用，包括椎间盘退变、肿瘤发生和血管抑制作用、儿科中风、性腺分化、滋养细胞浸润以及与精神分裂症和哮喘的遗传连锁，特别关注其在关节炎和炎症中的作用；并以 ADAMTS-12 的观点研究及其作为各种疾病和病症有希望的诊断和治疗靶标的潜力结束。
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