骨关节炎发病机制——一个涉及整个关节的复杂过程。
Osteoarthritis pathogenesis - a complex process that involves the entire joint.
作者信息
Man G S, Mologhianu G
机构信息
"Carol Davila" University of Medicine and Pharmacy, Gastroenterology Department, Emergency University Hospital, Bucharest.
"Carol Davila" University of Medicine and Pharmacy, Department of Rehabilitation Medicine, 3rd Rehabilitation Clinic of National Institute of Rehabilitation, Physical Medicine and Balneology, Bucharest.
出版信息
J Med Life. 2014 Mar 15;7(1):37-41. Epub 2014 Mar 25.
Abstract
Osteoarthritis is the most common joint disorder and a major cause of disability with a major socio-economic impact. In these circumstances is very important to understand its pathogenesis. Although previous research focused primarily on changes in the articular cartilage, more recent studies have highlighted the importance of the subchondral bone, synovium, menisci, ligaments, periarticular muscles and nerves. Now osteoarthritis is viewed as a multifactorial disease affecting the whole joint.
摘要
骨关节炎是最常见的关节疾病，也是导致残疾的主要原因，具有重大的社会经济影响。在这种情况下，了解其发病机制非常重要。尽管先前的研究主要集中在关节软骨的变化上，但最近的研究强调了软骨下骨、滑膜、半月板、韧带、关节周围肌肉和神经的重要性。现在，骨关节炎被视为一种影响整个关节的多因素疾病。
相似文献
1
Osteoarthritis pathogenesis - a complex process that involves the entire joint.骨关节炎发病机制——一个涉及整个关节的复杂过程。
J Med Life. 2014 Mar 15;7(1):37-41. Epub 2014 Mar 25.
2
Subchondral bone in osteoarthritis physiopathology: state-of-the art and perspectives.骨关节炎病理生理学中的软骨下骨：现状与展望
Biomed Mater Eng. 2009;19(4-5):311-6. doi: 10.3233/BME-2009-0596.
3
Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis.骨关节炎为什么会累及软骨下骨？软骨-骨界面在骨关节炎中的重要性。
Osteoporos Int. 2012 Dec;23 Suppl 8:S841-6. doi: 10.1007/s00198-012-2161-0. Epub 2012 Nov 22.
4
The role of bone in osteoarthritis pathogenesis.骨在骨关节炎发病机制中的作用。
Rheum Dis Clin North Am. 2008 Aug;34(3):561-71. doi: 10.1016/j.rdc.2008.07.001.
5
Cartilage degradation in osteoarthritis: A process of osteochondral remodeling resembles the endochondral ossification in growth plate?骨关节炎中的软骨降解：类似于生长板的软骨内骨化过程的骨软骨重塑？
Med Hypotheses. 2018 Dec;121:183-187. doi: 10.1016/j.mehy.2018.08.023. Epub 2018 Aug 27.
6
Role of bone in osteoarthritis pathogenesis.骨在骨关节炎发病机制中的作用。
Med Clin North Am. 2009 Jan;93(1):25-35, xv. doi: 10.1016/j.mcna.2008.09.006.
7
Pathophysiology of osteoarthritis.骨关节炎的病理生理学
Vet Res Commun. 2003 Sep;27 Suppl 1:75-8. doi: 10.1023/b:verc.0000014121.05759.f8.
8
Osteoarthritis of the temporomandibular joint organ and its relationship to disc displacement.颞下颌关节器官的骨关节炎及其与盘移位的关系。
J Orofac Pain. 2001 Summer;15(3):193-205.
9
Biological aspects of early osteoarthritis.早期骨关节炎的生物学方面。
Knee Surg Sports Traumatol Arthrosc. 2012 Mar;20(3):407-22. doi: 10.1007/s00167-011-1705-8. Epub 2011 Oct 19.
10
Joint homeostasis, restoration, and remodeling in osteoarthritis.骨关节炎中的关节稳态、修复与重塑
Best Pract Res Clin Rheumatol. 2008 Apr;22(2):209-20. doi: 10.1016/j.berh.2007.12.001.
引用本文的文献
1
Breaking Down Osteoarthritis: Exploring Inflammatory and Mechanical Signaling Pathways.剖析骨关节炎：探索炎症和机械信号通路
Life (Basel). 2025 Aug 4;15(8):1238. doi: 10.3390/life15081238.
2
Anti-osteoarthritis effect of a standardized extract in monosodium iodoacetate-induced osteoarthritis rats.标准化提取物对碘乙酸钠诱导的骨关节炎大鼠的抗骨关节炎作用
Nutr Res Pract. 2025 Aug;19(4):537-553. doi: 10.4162/nrp.2025.19.4.537. Epub 2025 Mar 10.
3
Thick or Thin? Implications of Cartilage Architecture for Osteoarthritis Risk in Sedentary Lifestyles.厚还是薄？软骨结构对久坐生活方式下骨关节炎风险的影响。
Biomedicines. 2025 Jul 6;13(7):1650. doi: 10.3390/biomedicines13071650.
4
The articularis genu as a surrogate for structural determinants of peri-articular myopenia in osteoarthritis.股关节肌作为骨关节炎关节周围肌少症结构决定因素的替代指标。
Sci Rep. 2025 Jul 6;15(1):24144. doi: 10.1038/s41598-025-08095-y.
5
Zwitterionic poly-carboxybetaine-dexamethasone conjugates do not alleviate cartilage degeneration and synovitis in the collagenase-induced osteoarthritis model in rats.两性离子型聚羧基甜菜碱-地塞米松共轭物不能减轻胶原酶诱导的大鼠骨关节炎模型中的软骨退变和滑膜炎。
Sci Rep. 2025 Jul 1;15(1):20501. doi: 10.1038/s41598-025-93247-3.
6
Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes.大麻二酚是人类关节软骨细胞中铁死亡的潜在抑制剂。
J Cell Mol Med. 2025 Jul;29(13):e70592. doi: 10.1111/jcmm.70592.
7
Development and In Vitro Characterization of Azithromycin-PLGA Nanoparticles Loaded Thermoresponsive Hydrogels: A Quality by Design Approach Toward Intra-Articular Delivery of Macrolides.载阿奇霉素的聚乳酸-羟基乙酸共聚物纳米粒温敏水凝胶的研制及其体外特性：基于质量源于设计理念的大环内酯类药物关节腔内给药研究
AAPS PharmSciTech. 2025 Jun 26;26(6):171. doi: 10.1208/s12249-025-03170-z.
8
Identification and validation of aging related genes in osteoarthritis.骨关节炎中衰老相关基因的鉴定与验证
Front Genet. 2025 May 30;16:1561644. doi: 10.3389/fgene.2025.1561644. eCollection 2025.
9
Osteo-F, a Newly Developed Herbal Formula, Ameliorates Osteoarthritis Through the NF-κB/IκB/JNK Pathway Based on Network Pharmacology.骨宝F，一种新研发的草药配方，基于网络药理学通过NF-κB/IκB/JNK信号通路改善骨关节炎。
Food Sci Nutr. 2025 May 11;13(5):e70239. doi: 10.1002/fsn3.70239. eCollection 2025 May.
10
Spatial transcriptomic applications in orthopedics.空间转录组学在骨科中的应用。
Connect Tissue Res. 2025 Jul;66(4):227-238. doi: 10.1080/03008207.2025.2501703. Epub 2025 May 10.
本文引用的文献
1
Clinical significance of bone changes in osteoarthritis.骨关节炎的骨骼变化的临床意义。
Ther Adv Musculoskelet Dis. 2012 Aug;4(4):259-67. doi: 10.1177/1759720X12437354.
2
Biomechanics and pathomechanisms of osteoarthritis.骨关节炎的生物力学和病理机制。
Swiss Med Wkly. 2012 Jul 19;142:w13583. doi: 10.4414/smw.2012.13583. eCollection 2012.
3
Meniscus pathology, osteoarthritis and the treatment controversy.半月板病变、骨关节炎与治疗争议。
Nat Rev Rheumatol. 2012 May 22;8(7):412-9. doi: 10.1038/nrrheum.2012.69.
4
Histological examination of collagen and proteoglycan changes in osteoarthritic menisci.骨关节炎半月板中胶原蛋白和蛋白聚糖变化的组织学检查
Open Rheumatol J. 2012;6:24-32. doi: 10.2174/1874312901206010024. Epub 2012 Apr 19.
5
Biomechanical considerations in the pathogenesis of osteoarthritis of the knee.膝关节骨关节炎发病机制中的生物力学考虑因素。
Knee Surg Sports Traumatol Arthrosc. 2012 Mar;20(3):423-35. doi: 10.1007/s00167-011-1818-0. Epub 2011 Dec 16.
6
Diagnosis of osteoarthritis: imaging.骨关节炎的诊断：影像学检查。
Bone. 2012 Aug;51(2):278-88. doi: 10.1016/j.bone.2011.11.019. Epub 2011 Dec 3.
7
Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis.人类膝关节半月板在衰老和骨关节炎中的大体形态和组织病理学分析。
Osteoarthritis Cartilage. 2011 Sep;19(9):1132-41. doi: 10.1016/j.joca.2011.05.008. Epub 2011 Jun 1.
8
Developments in osteoarthritis.骨关节炎的进展
Rheumatology (Oxford). 2011 Feb;50(2):245-7. doi: 10.1093/rheumatology/keq373.
9
The bone-cartilage unit in osteoarthritis.骨软骨单位在骨关节炎中的作用。
Nat Rev Rheumatol. 2011 Jan;7(1):43-9. doi: 10.1038/nrrheum.2010.197. Epub 2010 Dec 7.
10
Thrombin-cleaved osteopontin levels in synovial fluid correlate with disease severity of knee osteoarthritis.滑液中凝血酶裂解的骨桥蛋白水平与膝骨关节炎的疾病严重程度相关。
J Rheumatol. 2011 Jan;38(1):129-34. doi: 10.3899/jrheum.100637. Epub 2010 Nov 1.
Zotero 插件