Zhu Cairong, Bassig Bryan A, Shi Kunchong, Boyle Peter, Guo Huan, Zheng Tongzhang
West China School of Public Health, Sichuan University, Chengdu, 610041, China.
Cancer Causes Control. 2014 Aug;25(8):923-31. doi: 10.1007/s10552-014-0391-5. Epub 2014 May 31.
Hodgkin's lymphoma (HL) is one of the most common cancers among young adults. We investigated the time trends for HL among the 20-44 age group in the USA by gender to identify the potential factors accounting for the incidence trends.
Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program for 1973-2010, we conducted age-period-cohort modeling to evaluate birth cohort patterns on incidence trends of HL over time.
For all races combined, the age-adjusted incidence patterns were similar to that of whites. The birth cohort patterns for whites and all races were similar, but the patterns differed according to gender. Specifically, except for the 1970-1975 birth cohort, all other birth cohorts showed an increasing birth cohort trend for females. Conversely, there was a decreasing cohort trend in males beginning in the 1960 birth cohort regardless of the assumptions of the period effect.
The established risk factors for HL can seemingly not explain the gender disparities of the cohort pattern, which necessitates further analytical epidemiological studies to explore the risk factors for this disease with respect to potential differences by gender and by histological subtype.
霍奇金淋巴瘤（HL）是年轻成年人中最常见的癌症之一。我们按性别调查了美国20至44岁年龄组中HL的时间趋势，以确定导致发病率趋势的潜在因素。
利用美国国家癌症研究所监测、流行病学和最终结果计划1973 - 2010年的数据，我们进行了年龄 - 时期 - 队列建模，以评估出生队列模式随时间推移对HL发病率趋势的影响。
所有种族合并来看，年龄调整后的发病率模式与白人相似。白人和所有种族的出生队列模式相似，但根据性别有所不同。具体而言，除了1970 - 1975年出生队列外，所有其他出生队列中女性的出生队列趋势呈上升趋势。相反，无论时期效应的假设如何，自1960年出生队列开始，男性的队列趋势呈下降趋势。
已确定的HL危险因素似乎无法解释队列模式中的性别差异，这需要进一步的分析性流行病学研究，以探索该疾病在性别和组织学亚型方面潜在差异的危险因素。
