Courtney Kelly E, Ghahremani Dara G, London Edythe D, Ray Lara A
Department of Psychology, University of California, Los Angeles, United States.
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
Drug Alcohol Depend. 2014 Aug 1;141:21-6. doi: 10.1016/j.drugalcdep.2014.04.026. Epub 2014 May 14.
Given numerous reports implicating involvement of the precuneus in cue-reactivity paradigms, the goal of this investigation was to examine the relationship between activation of the precuneus in response to drug cues and measures of subjective craving and severity of dependence in volunteers who were comorbid for alcohol and nicotine abuse.
Forty research participants, who all reported heavy drinking and daily smoking, were recruited (15 women; 70% Caucasian; mean age=31.2 years) for a functional magnetic resonance imaging (fMRI) session involving a cigarette video-cues task and an alcohol taste-cues task. Mean precuneus activation from both tasks during cue presentation was subjected to bivariate correlation analyses with indices of dependence severity and subjective craving.
Precuneus activation in the contrast of Cigarette Cues vs. Control Cues was positively correlated with scores on the Fagerström Test of Nicotine Dependence (r=0.389, p=0.016), and activation in the Alcohol Cues vs. Control Cues contrast was positively correlated with Alcohol Dependence Scale scores (r=0.338, p=0.038). No correlations with subjective craving were observed (ps>0.05).
These findings indicate that the precuneus is involved in cue reactivity for both cigarettes and alcohol, and that this involvement is moderated by severity of drug dependence. The precuneus may be a cortical locus for neuroplastic changes related to drug dependence.
鉴于有大量报告表明楔前叶参与线索反应范式，本研究的目的是在酒精和尼古丁滥用共病的志愿者中，研究对药物线索产生反应时楔前叶的激活与主观渴望程度及依赖严重程度之间的关系。
招募了40名研究参与者（15名女性；70%为白种人；平均年龄 = 31.2岁），他们均报告有大量饮酒和每日吸烟的情况，进行一项功能磁共振成像（fMRI）实验，该实验包括香烟视频线索任务和酒精味道线索任务。在呈现线索期间，对两项任务中楔前叶的平均激活情况与依赖严重程度指标和主观渴望程度进行双变量相关分析。
在香烟线索与对照线索对比中楔前叶的激活与尼古丁依赖的Fagerström测试得分呈正相关（r = 0.389，p = 0.016），在酒精线索与对照线索对比中楔前叶的激活与酒精依赖量表得分呈正相关（r = 0.338，p = 0.038）。未观察到与主观渴望程度的相关性（p>0.05）。
这些发现表明楔前叶参与了对香烟和酒精的线索反应，并且这种参与受药物依赖严重程度的调节。楔前叶可能是与药物依赖相关的神经可塑性变化的皮质位点。
