Dissociating effects of global SWS disruption and healthy aging on waking performance and daytime sleepiness.

STUDY OBJECTIVE

To contrast the effects of slow wave sleep (SWS) disruption and age on daytime functioning.

DESIGN

Daytime functioning was contrasted in three age cohorts, across two parallel 4-night randomized groups (baseline, two nights of SWS disruption or control, recovery sleep).

SETTING

Sleep research laboratory.

PARTICIPANTS

44 healthy young (20-30 y), 35 middle-aged (40-55 y), and 31 older (66-83 y) men and women.

INTERVENTIONS

Acoustic stimulation contingent on appearance of slow waves.

MEASUREMENTS AND RESULTS

Cognitive performance was assessed before sleep latency tests at five daily time-points. SWS disruption resulted in less positive affect, slower or impaired information processing and sustained attention, less precise motor control, and erroneous implementation, rather than inhibition, of well-practiced actions. These performance impairments had far smaller effect sizes than the increase in daytime sleepiness and differed from baseline to the same extent for each age group. At baseline, younger participants performed better than older participants across many cognitive domains, with largest effects on executive function, response time, sustained attention, and motor control. At baseline, the young were sleepier than other age groups.

CONCLUSIONS

SWS has been considered a potential mediator of age-related decline in performance, although the effects of SWS disruption on daytime functioning have not been quantified across different cognitive domains nor directly compared to age-related changes in performance. The data imply that two nights of SWS disruption primarily leads to an increase in sleepiness with minor effects on other aspects of daytime functioning, which are different from the substantial effects of age.